Reactome | MAP3K5 phosphorylates MKK3 and MKK6

MAP3K5 phosphorylates MKK3 and MKK6

Stable Identifier

R-HSA-3228469

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MAP3K5 (ASK1) phosphorylates and activates MAP2K3 (MKK3) and MAP2K6 (MKK6) (Ichijo et al. 1997). A conserved docking site, DVD, at the C-terminus of MAP2K3 and MAP2K6 is needed for the interaction with MAP3K5 and MAP3K5-mediated activation (Takekawa et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15866172	Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases Tatebayashi, K, Saito, H, Takekawa, M	Mol. Cell	2005
8974401	Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways Nishida, E, Irie, K, Ichijo, H, Matsumoto, K, Saitoh, M, ten Dijke, P, Gotoh, Y, Moriguchi, T, Miyazono, K, Takagi, M	Science	1997