MAP3K5 phosphorylates MKK3 and MKK6

Stable Identifier
R-HSA-3228469
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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MAP3K5 (ASK1) phosphorylates and activates MAP2K3 (MKK3) and MAP2K6 (MKK6) (Ichijo et al. 1997). A conserved docking site, DVD, at the C-terminus of MAP2K3 and MAP2K6 is needed for the interaction with MAP3K5 and MAP3K5-mediated activation (Takekawa et al. 2005).

Literature References
PubMed ID Title Journal Year
8974401 Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

Ichijo, H, Nishida, E, Irie, K, ten Dijke, P, Saitoh, M, Moriguchi, T, Takagi, M, Matsumoto, K, Miyazono, K, Gotoh, Y

Science 1997
15866172 Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases

Takekawa, M, Tatebayashi, K, Saito, H

Mol. Cell 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of MAP3K5 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created