Reactome | MAP3K5 phosphorylates MKK3 and MKK6

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MAP3K5 phosphorylates MKK3 and MKK6 Show undefined attributes

catalystActivity	[CatalystActivity:10392002] protein serine/threonine kinase activity of MAP3K5 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10332713] Weiser, Joel, 2026-03-16
dbId	10392004
displayName	MAP3K5 phosphorylates MKK3 and MKK6
eventOf	[Pathway:R-BTA-2559580] Oxidative Stress Induced Senescence - Bos taurus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-BTA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus - Bos taurus
inferredFrom	[Reaction:R-HSA-3228469] MAP3K5 phosphorylates MKK3 and MKK6 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-BTA-167916] MAP2K3,MAP2K6 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAP3K5 phosphorylates MKK3 and MKK6
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-BTA-167984] p-S218,T222-MAP2K3, p-S207,T211-MAP2K6 [cytosol]
precedingEvent	[Reaction:R-BTA-3225851] ROS oxidize thioredoxin and activate MAP3K5 - Bos taurus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48898] Bos taurus
stId	R-BTA-3228469
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-BTA-2559580] Oxidative Stress Induced Senescence
(precedingEvent)	[Reaction:R-BTA-450296] Phosphorylated MKK3/MKK6 migrates to nucleus
(inferredTo)	[Reaction:R-HSA-3228469] MAP3K5 phosphorylates MKK3 and MKK6

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