TP53INP1 and HIPK2 bind TP53

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
TP53INP1 (p53INP1) forms a complex with TP53 and its regulating kinase HIPK2 (Tomasini et al. 2003, Okamura et al. 2001). HIPK2 undergoes autophosphorylation in response to DNA damage, but the mechanism and the identity of autophosphorylation sites have not yet been fully elucidated (Bitomsky et al. 2013, Saul et al. 2013, Siepi et al. 2013). Autophosphorylation enables HIPK2 binding to PIN1. PIN1 likely facilitates a conformational change that enables HIPK2 to phosphorylate its targets, including TP53 (Bitomsky et al. 2013).
Literature References
PubMed ID Title Journal Year
23485397 HIPK2 catalytic activity and subcellular localization are regulated by activation-loop Y354 autophosphorylation

Gatti, V, Soddu, S, Siepi, F, Crescenzi, M, Camerini, S

Biochim. Biophys. Acta 2013
12851404 TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity

Malissen, B, Tomasini, R, Carrier, A, Dusetti, NJ, Isnardon, D, Samir, AA, Cecchinelli, B, Soddu, S, Iovanna, JL, Dagorn, JC

J. Biol. Chem. 2003
11511362 p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

Arakawa, H, Nakanishi, H, Nakamura, Y, Monden, M, Taya, Y, Ng, CC, Tanaka, T, Okamura, S

Mol. Cell 2001
23000554 HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop

de la Vega, L, Schmitz, ML, Fritz-Wolf, K, Braun, T, Becker, K, Saul, VV, Milanovic, M, Kr├╝ger, M

J Mol Cell Biol 2013
24145406 Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death

Schultheiss, K, Greiner, V, Sombroek, D, Moritz, C, Glas, C, Peri, F, Del Sal, G, Conrad, E, Polonio-Vallon, T, Hofmann, TG, Mantovani, F, Herbel, C, Bitomsky, N

Proc. Natl. Acad. Sci. U.S.A. 2013
Orthologous Events
Cite Us!