E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA

Stable Identifier
R-HSA-3209109
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E2F1/E2F2/E2F3 and SP1 stimulate transcription of p14ARF mRNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
E2F1, E2F2 or E2F3 in complex with SP1 stimulates p14ARF transcription (Parisi et al. 2002). Therefore, increased activity of E2F1, E2F2 or E2F3, which may result from the loss of function of the tumor suppressor protein RB1, an inhibitor of E2F1/2/3, leads to an increased level of p14ARF (Komori et al. 2005).
Literature References
PubMed ID Title Journal Year
11883935 Transcriptional regulation of the human tumor suppressor p14(ARF) by E2F1, E2F2, E2F3, and Sp1-like factors

Parisi, T, Calabrò, V, La Mantia, G, Pollice, A, Di Cristofano, A

Biochem. Biophys. Res. Commun. 2002
16211008 Distinct E2F-mediated transcriptional program regulates p14ARF gene expression

Iwanaga, R, Ohtani, K, Nakamura, M, Enomoto, M, Komori, H

EMBO J. 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
RB1 [nucleoplasm] (Homo sapiens)
Positively by
Regulator
DP1/2: E2F1/2/3: SP1: CDKN2A Gene [nucleoplasm] (Homo sapiens)
Active Unit
SP1 [nucleoplasm]
E2F1,E2F2,E2F3:TFDP1,TFDP2 [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-01)
Cite Us!