Reactome | MMAB adenosylates cob(I)alamin

Schema > Reaction > Entries

MMAB adenosylates cob(I)alamin Show undefined attributes

authored	[InstanceEdit:196747] Jassal, B, 2007-04-24 08:38:46
catalystActivity	[CatalystActivity:3159301] transferase activity, transferring alkyl or aryl (other than methyl) groups of 3xMMAB [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9759577] transferase activity, transferring alkyl or aryl (other than methyl) groups of 3xMMAB [mitochondrial matrix] Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:3159299] Jassal, Bijay, 2013-02-20
dbId	3159253
displayName	MMAB adenosylates cob(I)alamin
edited	[InstanceEdit:3159299] Jassal, Bijay, 2013-02-20
eventOf	[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-3159259] MMAA:MUT binds AdoCbl - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-3149564] cob(II)alamin [mitochondrial matrix] [SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9758714] Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking [LiteratureReference:9759565] Sacrificial Cobalt-Carbon Bond Homolysis in Coenzyme B₁₂ as a Cofactor Conservation Strategy [LiteratureReference:3159257] Functional characterization and mutation analysis of human ATP:Cob(I)alamin adenosyltransferase [LiteratureReference:3159291] Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements [LiteratureReference:3159296] Identification of the human and bovine ATP:Cob(I)alamin adenosyltransferase cDNAs based on complementation of a bacterial mutant [LiteratureReference:9759571] Spectroscopic evidence for the formation of a four-coordinate Co2+ cobalamin species upon binding to the human ATP:cobalamin adenosyltransferase
modified	[InstanceEdit:10818988] Wright, Adam, 2024-03-08
name	MMAB adenosylates cob(I)alamin 2 ATP + 2 cob(II)alamin + reduced (electron-transfer flavoprotein) => 2 adenosylcob(III)alamin + 3 H(+) + oxidized (electron-transfer flavoprotein) + 2 triphosphate
orthologousEvent	[Reaction:R-MMU-3159253] MMAB adenosylates cob(I)alamin - Mus musculus [Reaction:R-DDI-3159253] MMAB adenosylates cob(I)alamin - Dictyostelium discoideum [Reaction:R-CEL-3159253] MMAB adenosylates cob(I)alamin - Caenorhabditis elegans [Reaction:R-GGA-3159253] MMAB adenosylates cob(I)alamin - Gallus gallus [Reaction:R-XTR-3159253] MMAB adenosylates cob(I)alamin - Xenopus tropicalis [Reaction:R-SSC-3159253] MMAB adenosylates cob(I)alamin - Sus scrofa [Reaction:R-BTA-3159253] MMAB adenosylates cob(I)alamin - Bos taurus [Reaction:R-CFA-3159253] MMAB adenosylates cob(I)alamin - Canis familiaris [Reaction:R-RNO-3159253] MMAB adenosylates cob(I)alamin - Rattus norvegicus
output	2 × [SimpleEntity:R-ALL-3159297] AdoCbl [mitochondrial matrix] [SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-3159274] PPP [mitochondrial matrix]
precedingEvent	[BlackBoxEvent:R-HSA-3149563] MMADHC targets transport of cytosolic cob(II)alamin to mitochondria - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3159253
summation	[Summation:3162925] In a complex reaction, MMAB (mitochondrial cob(I)yrinic acid...

Referrals

(normalReaction)	[FailedReaction:R-HSA-3322125] Defective MMAB does not transfer adenosyl group from ATP to B12s
(hasEvent)	[Pathway:R-HSA-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)	[Reaction:R-HSA-3159259] MMAA:MUT binds AdoCbl