Reactome | MMAB adenosylates cob(I)alamin

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MMAB adenosylates cob(I)alamin Show undefined attributes

catalystActivity	[CatalystActivity:10605513] corrinoid adenosyltransferase activity of 3xMMAB [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10605515
displayName	MMAB adenosylates cob(I)alamin
eventOf	[Pathway:R-DRE-9759218] Cobalamin (Cbl) metabolism - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-3159259] MMAA:MUT binds AdoCbl - Danio rerio
inferredFrom	[Reaction:R-HSA-3159253] MMAB adenosylates cob(I)alamin - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113593] ATP [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-3149564] cob(II)alamin [mitochondrial matrix] [SimpleEntity:R-ALL-31649] FADH2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	MMAB adenosylates cob(I)alamin 2 ATP + 2 cob(II)alamin + reduced (electron-transfer flavoprotein) => 2 adenosylcob(III)alamin + 3 H(+) + oxidized (electron-transfer flavoprotein) + 2 triphosphate
output	2 × [SimpleEntity:R-ALL-3159297] AdoCbl [mitochondrial matrix] [SimpleEntity:R-ALL-113596] FAD [mitochondrial matrix] 3 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-3159274] PPP [mitochondrial matrix]
precedingEvent	[Reaction:R-DRE-3149563] MMADHC targets transport of cytosolic cob(II)alamin to mitochondria - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-3159253
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-9759218] Cobalamin (Cbl) metabolism
(precedingEvent)	[Reaction:R-DRE-3159259] MMAA:MUT binds AdoCbl
(inferredTo)	[Reaction:R-HSA-3159253] MMAB adenosylates cob(I)alamin

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