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Regulation of innate immune responses to cytosolic DNA
Stable Identifier
R-HSA-3134975
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
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Innate immune responses are coordinated and regulated to provide an efficient first line of defense against pathogens and at the same time to prevent host self-damage. Here we present some regulatory events involved in the detection of cytosolic nucleic acids.
Literature References
PubMed ID
Title
Journal
Year
19362700
Regulation of the cytosolic DNA-sensing system in innate immunity: a current view
Savitsky, D
,
Tamura, T
,
Yanai, H
,
Taniguchi, T
Curr. Opin. Immunol.
2009
23706668
Immune Sensing of DNA
Bowie, AG
,
Paludan, SR
Immunity
2013
Participants
Events
DDX41 ubiquitination by TRIM21
(Homo sapiens)
STING binds TRIM32 or TRIM56
(Homo sapiens)
STING ubiquitination by TRIM32 or TRIM56
(Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within dsDNA:ZBP1:TBK1
(Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3
(Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1
(Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3
(Homo sapiens)
Regulation by TREX1
(Homo sapiens)
Participates
as an event of
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Event Information
Go Biological Process
regulation of type I interferon production (0032479)
Orthologous Events
Regulation of innate immune responses to cytosolic DNA (Bos taurus)
Regulation of innate immune responses to cytosolic DNA (Caenorhabditis elegans)
Regulation of innate immune responses to cytosolic DNA (Canis familiaris)
Regulation of innate immune responses to cytosolic DNA (Danio rerio)
Regulation of innate immune responses to cytosolic DNA (Drosophila melanogaster)
Regulation of innate immune responses to cytosolic DNA (Gallus gallus)
Regulation of innate immune responses to cytosolic DNA (Mus musculus)
Regulation of innate immune responses to cytosolic DNA (Rattus norvegicus)
Regulation of innate immune responses to cytosolic DNA (Sus scrofa)
Regulation of innate immune responses to cytosolic DNA (Xenopus tropicalis)
Authored
Shamovsky, V (2013-02-06)
Reviewed
Wu, J (2013-05-22)
Jin, L (2013-05-22)
D'Eustachio, P (2013-02-11)
Created
Shamovsky, V (2013-02-13)
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