Reactome | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

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LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Show undefined attributes

authored	[InstanceEdit:3065946] Shamovsky, V, 2013-02-06
created	[InstanceEdit:3134971] Shamovsky, V, 2013-02-13
dbId	3134973
displayName	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
eventOf	[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-3134896] LRR FLII-interacting protein 1 binds dsDNA - Homo sapiens [Reaction:R-HSA-3134901] LRR FLII-interacting protein 1 associates with beta-catenin - Homo sapiens [Reaction:R-HSA-3134904] Phosphorylation of beta-catenin at Ser552 - Homo sapiens [BlackBoxEvent:R-HSA-3134914] Beta-catenin migrates to the nucleus - Homo sapiens [Reaction:R-HSA-3134883] Beta-catenin enhances association of IRF3 with CBP/p300 - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2017-09-27
literatureReference	[LiteratureReference:3134936] The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway [LiteratureReference:3134967] TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
orthologousEvent	[Pathway:R-MMU-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Mus musculus [Pathway:R-CEL-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Caenorhabditis elegans [Pathway:R-DME-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Drosophila melanogaster [Pathway:R-GGA-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Gallus gallus [Pathway:R-XTR-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Xenopus tropicalis [Pathway:R-DRE-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Danio rerio [Pathway:R-SSC-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Sus scrofa [Pathway:R-BTA-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Bos taurus [Pathway:R-CFA-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Canis familiaris [Pathway:R-RNO-3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - Rattus norvegicus
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3110284] D'Eustachio, P, 2013-02-11 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-3134973
summation	[Summation:3134968] Leucine-rich repeat flightless-interacting protein 1 (LRRFIP...
updateTrackers	[UpdateTracker:9863996] Update Tracker - [Pathway:3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - v88:[updateContainedRLE] [UpdateTracker:9780562] Update Tracker - [Pathway:3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - v62:[updateContainedRLE]

Referrals

(updatedInstance)	[UpdateTracker:9863996] Update Tracker - [Pathway:3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - v88:[updateContainedRLE] [UpdateTracker:9780562] Update Tracker - [Pathway:3134973] LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production - v62:[updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-1834949] Cytosolic sensors of pathogen-associated DNA

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