Reactome | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

Stable Identifier

R-HSA-3134973

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production

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Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) can bind exogenous double-stranded RNA and double-stranded DNA (Wilson SA et al. 1998; Yang P et al. 2010). LRRFIP1 was shown to mediate Listeria monocytogenes- and vesicular stomatitis virus (VSV)-induced IFN-beta production in mouse primary macrophages by regulating beta-catenin activity. Beta-catenin possibly functions as a transcriptional cofactor of IRF3 to initiate Ifnb1 transcription (Yang P et al. 2010).

Literature References

PubMed ID	Title	Journal	Year
9671805	TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I Wilson, SA, Brown, EC, Kingsman, AJ, Kingsman, SM	Nucleic Acids Res.	1998
20453844	The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway Yang, P, An, H, Liu, X, Wen, M, Zheng, Y, Rui, Y, Cao, X	Nat. Immunol.	2010