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Schema
>
BlackBoxEvent
>
Entries
CD320-mediated TCN2:RCbl uptake and delivery to lysosome
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authored
[InstanceEdit:3000082] Jassal, Bijay, 2013-01-24
catalystActivity
[CatalystActivity:9759384] cargo receptor activity of TCN2:RCbl:CD320 [plasma membrane]
catalystActivityReference
[CatalystActivityReference:9759389] cargo receptor activity of TCN2:Cbl:CD320 [plasma membrane] The binding properties of the human receptor for the cellular uptake of vitamin B12
category
omitted
compartment
[Compartment:876] plasma membrane
[Compartment:161320] lysosomal lumen
[Compartment:984] extracellular region
created
[InstanceEdit:3000082] Jassal, Bijay, 2013-01-24
dbId
3000112
deleted
[Deleted:9758905] Deletion of instance: 3000109
displayName
CD320-mediated TCN2:RCbl uptake and delivery to lysosome
edited
[InstanceEdit:3000082] Jassal, Bijay, 2013-01-24
eventOf
[Pathway:R-HSA-9758890] Transport of RCbl within the body - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-3000263] TCN2:RCbl is degraded to release RCbl - Homo sapiens
input
[Complex:R-HSA-3000089] TCN2:RCbl:CD320 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:9758726] Structural basis of transcobalamin recognition by human CD320 receptor
[LiteratureReference:3000097] Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
CD320-mediated TCN2:RCbl uptake and delivery to lysosome
orthologousEvent
[BlackBoxEvent:R-GGA-3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - Gallus gallus
[BlackBoxEvent:R-BTA-3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - Bos taurus
[BlackBoxEvent:R-RNO-3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - Rattus norvegicus
[BlackBoxEvent:R-MMU-3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - Mus musculus
output
[EntityWithAccessionedSequence:R-HSA-2980909] CD320 [plasma membrane]
[Complex:R-HSA-3000242] TCN2:RCbl [lysosomal lumen]
precedingEvent
[Reaction:R-HSA-3000122] CD320 binds extracellular TCN2:RCbl - Homo sapiens
releaseDate
2013-06-11
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-3000112
summation
[Summation:3000073] Once the complex of transcobalamin 2 and cobalamins (RCbl) b...
updateTrackers
[UpdateTracker:9787220] Update Tracker - [BlackBoxEvent:3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - v46:[modifyText]
[UpdateTracker:9775044] Update Tracker - [BlackBoxEvent:3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - v80:[addCatalystActivity, addLiteratureReference, addOutput, add_removeInput, modifyText]
Referrals
(updatedInstance)
[UpdateTracker:9787220] Update Tracker - [BlackBoxEvent:3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - v46:[modifyText]
[UpdateTracker:9775044] Update Tracker - [BlackBoxEvent:3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - v80:[addCatalystActivity, addLiteratureReference, addOutput, add_removeInput, modifyText]
(replacementInstances)
[Deleted:9758905] Deletion of instance: 3000109
(hasEvent)
[Pathway:R-HSA-9758890] Transport of RCbl within the body
(precedingEvent)
[BlackBoxEvent:R-HSA-3000263] TCN2:RCbl is degraded to release RCbl
[NegativePrecedingEvent:9764872] Futile Cycle: CD320-mediated TCN2:RCbl uptake and delivery to lysosome
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