Reactome | CD320 binds extracellular TCN2:RCbl

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CD320 binds extracellular TCN2:RCbl Show undefined attributes

authored	[InstanceEdit:3000082] Jassal, Bijay, 2013-01-24
catalystActivity	[CatalystActivity:3000088] cargo receptor activity of CD320 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9758899] cargo receptor activity of CD320 [plasma membrane] The binding properties of the human receptor for the cellular uptake of vitamin B12
category	transition
compartment	[Compartment:984] extracellular region [Compartment:74700] endosome membrane [Compartment:17940] endosome
created	[InstanceEdit:3000082] Jassal, Bijay, 2013-01-24
dbId	3000122
diseaseReaction	[FailedReaction:R-HSA-3325546] Defective CD320 does not transport extracellular TCII:Cbl to endosome - Homo sapiens
displayName	CD320 binds extracellular TCN2:RCbl
edited	[InstanceEdit:3000082] Jassal, Bijay, 2013-01-24
eventOf	[Pathway:R-HSA-9758890] Transport of RCbl within the body - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-2980909] CD320 [plasma membrane] [Complex:R-HSA-9759429] TCN2:RCbl [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:3000080] The binding properties of the human receptor for the cellular uptake of vitamin B12 [LiteratureReference:3000116] The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin [LiteratureReference:3000076] Positive newborn screen for methylmalonic aciduria identifies the first mutation in TCblR/CD320, the gene for cellular uptake of transcobalamin-bound vitamin B(12)
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	CD320 binds extracellular TCN2:RCbl
negativePrecedingEvent	[NegativePrecedingEvent:9764872] Futile Cycle: CD320-mediated TCN2:RCbl uptake and delivery to lysosome
orthologousEvent	[Reaction:R-GGA-3000122] CD320 binds extracellular TCN2:RCbl - Gallus gallus [Reaction:R-BTA-3000122] CD320 binds extracellular TCN2:RCbl - Bos taurus [Reaction:R-RNO-3000122] CD320 binds extracellular TCN2:RCbl - Rattus norvegicus [Reaction:R-MMU-3000122] CD320 binds extracellular TCN2:RCbl - Mus musculus
output	[Complex:R-HSA-3000089] TCN2:RCbl:CD320 [plasma membrane]
precedingEvent	[Reaction:R-HSA-3000074] TCN2 binds RCbl in the circulation - Homo sapiens
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3288227] D'Eustachio, P, 2013-04-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-3000122
summation	[Summation:3000094] The ubiquitously expressed CD320 antigen (CD320 aka transcob...
updateTrackers	[UpdateTracker:9786252] Update Tracker - [Reaction:3000122] CD320 binds extracellular TCN2:RCbl - v50:[modifyText] [UpdateTracker:9775146] Update Tracker - [Reaction:3000122] CD320 binds extracellular TCN2:RCbl - v80:[add_removeInput, modifyText] [UpdateTracker:9786997] Update Tracker - [Reaction:3000122] CD320 binds extracellular TCN2:RCbl - v46:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786252] Update Tracker - [Reaction:3000122] CD320 binds extracellular TCN2:RCbl - v50:[modifyText] [UpdateTracker:9775146] Update Tracker - [Reaction:3000122] CD320 binds extracellular TCN2:RCbl - v80:[add_removeInput, modifyText] [UpdateTracker:9786997] Update Tracker - [Reaction:3000122] CD320 binds extracellular TCN2:RCbl - v46:[modifyText]
(normalReaction)	[FailedReaction:R-HSA-3325546] Defective CD320 does not transport extracellular TCII:Cbl to endosome
(hasEvent)	[Pathway:R-HSA-9758890] Transport of RCbl within the body
(precedingEvent)	[BlackBoxEvent:R-HSA-3000112] CD320-mediated TCN2:RCbl uptake and delivery to lysosome

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