CD320-mediated TCN2:RCbl uptake and delivery to lysosome

Stable Identifier
R-HSA-3000112
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Once the complex of transcobalamin 2 and cobalamins (RCbl) bound to CD320 receptor (TCN2:RCbl:CD320) is internalised by endocytosis, CD320 dissociates, possibly facilitated by the low affinity of CD320 for TCN2 at acidic pH (Alam et al. 2016), to return to the plasma membrane (Youngdahl Turner et al. 1979), while TCN2:RCbl is delivered to lysosomes and degraded, releasing RCbl.

Literature References
PubMed ID Title Journal Year
759210 Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts

Mellman, IS, Youngdahl-Turner, P, Rosenberg, LE, Allen, RH

Exp. Cell Res. 1979
27411955 Structural basis of transcobalamin recognition by human CD320 receptor

Zenobi, R, Alam, A, Prinz, B, Locher, KP, Bloch, JS, Woo, JS, Chen, F, Schmitz, J, Root, K

Nat Commun 2016
Participants
Participates
Catalyst Activity

cargo receptor activity of TCN2:RCbl:CD320 [plasma membrane]

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