Endosomal TCII:Cbl translocates to lysosome

Stable Identifier
R-HSA-3000112
Type
Reaction [omitted]
Species
Homo sapiens
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Transcobalamin II (TCII, the product of the gene TCN2) degradation is necessary for cobalamin (Cbl) to be released from the complex and made available for binding to Cbl-dependant apoenzymes (Youngdahl-Turner et al. 1979). The TCII:Cbl complex translocates to lysosomes for degradation.

Literature References
PubMed ID Title Journal Year
759210 Protein mediated vitamin uptake. Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts

Youngdahl-Turner, P, Mellman, IS, Allen, RH, Rosenberg, LE

Exp. Cell Res. 1979
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