Reactome | COX10 transforms heme to heme O

Schema > Reaction > Entries

COX10 transforms heme to heme O Show undefined attributes

catalystActivity	[CatalystActivity:10692141] protoheme IX farnesyltransferase activity of COX10(?-443) [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10692143
displayName	COX10 transforms heme to heme O
eventOf	[Pathway:R-XTR-189451] Heme biosynthesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-2995334] COX15 transforms heme O to heme A - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-2995330] COX10 transforms heme to heme O - Homo sapiens
input	[SimpleEntity:R-ALL-2162257] FPP [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-9853511] heme b [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	COX10 transforms heme to heme O (2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o
output	[SimpleEntity:R-ALL-9865393] heme O [mitochondrial inner membrane] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-XTR-189465] FECH binds Fe2+ to PRIN9 to form heme - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2995330
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-189451] Heme biosynthesis
(precedingEvent)	[Reaction:R-XTR-2995334] COX15 transforms heme O to heme A
(inferredTo)	[Reaction:R-HSA-2995330] COX10 transforms heme to heme O

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