COX10 transforms heme to heme O

Stable Identifier
R-HSA-2995330
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix, mitochondrial inner membrane
Synonyms
(2E,6E)-farnesyl diphosphate + H2O + heme b => diphosphate + Fe(II)-heme o
ReviewStatus
5/5
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COX10 transforms heme to heme O
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Heme A and less frequently heme O function as prosthetic groups of heme-copper respiratory oxidases(Rivett et al. 2021). Mitochondrial protoheme IX farnesyltransferase (COX10) mediates the transformation of protoheme IX (heme) and farnesyl diphosphate (FAPP) to heme O (Glerum & Tzagoloff 1994). COX10 is highly expressed in muscle, heart and brain (Murakami et al. 1997).
Literature References
PubMed ID Title Journal Year
9177788 Genomic structure and expression of the human heme A:farnesyltransferase (COX10) gene

Murakami, T, Reiter, LT, Lupski, JR

Genomics 1997
34428995 Biosynthesis and trafficking of heme o and heme a: new structural insights and their implications for reaction mechanisms and prenylated heme transfer

Rivett, ED, Heo, L, Feig, M, Hegg, EL

Crit Rev Biochem Mol Biol 2021
8078902 Isolation of a human cDNA for heme A:farnesyltransferase by functional complementation of a yeast cox10 mutant

Glerum, DM, Tzagoloff, A

Proc. Natl. Acad. Sci. U.S.A. 1994
Participants
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Output
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as an event of
Catalyst Activity

protoheme IX farnesyltransferase activity of COX10(?-443) [mitochondrial inner membrane]

Physical Entity
COX10(?-443) [mitochondrial inner membrane] (Homo sapiens)
Activity
protoheme IX farnesyltransferase activity (GO:0008495)
Orthologous Events
COX10 transforms heme to heme O (Bos taurus)
COX10 transforms heme to heme O (Caenorhabditis elegans)
COX10 transforms heme to heme O (Canis familiaris)
COX10 transforms heme to heme O (Danio rerio)
COX10 transforms heme to heme O (Dictyostelium discoideum)
COX10 transforms heme to heme O (Drosophila melanogaster)
COX10 transforms heme to heme O (Gallus gallus)
COX10 transforms heme to heme O (Mus musculus)
COX10 transforms heme to heme O (Plasmodium falciparum)
COX10 transforms heme to heme O (Rattus norvegicus)
COX10 transforms heme to heme O (Saccharomyces cerevisiae)
COX10 transforms heme to heme O (Schizosaccharomyces pombe)
COX10 transforms heme to heme O (Sus scrofa)
COX10 transforms heme to heme O (Xenopus tropicalis)
Authored
Jassal, B  (2013-01-22)
Reviewed
D'Eustachio, P  (2013-04-15)
Matthews, L  (2024-03-11)
Created
Jassal, B  (2013-01-22)
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