Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2

Stable Identifier
R-HSA-2974731
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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Gamma-secretase cleaves CNTN1:NOTCH2 to release NICD2
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Binding of CNTN1 to NOTCH2 results in release of the intracellular domain of NOTCH2, NICD2 in a gamma-secretase-dependent way. The role of ADAM10 metalloprotease in this process has not been directly examined (Hu et al. 2003).

Literature References
PubMed ID Title Journal Year
14567914 F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

Hu, QD, Ang, BT, Karsak, M, Hu, WP, Cui, XY, Duka, T, Takeda, Y, Chia, W, Sankar, N, Ng, YK, Ling, EA, Maciag, T, Small, D, Trifonova, R, Kopan, R, Okano, H, Nakafuku, M, Chiba, S, Hirai, H, Aster, JC, Schachner, M, Pallen, CJ, Watanabe, K, Xiao, ZC

Cell 2003
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
This event is regulated
Positively by
Inferred From
Gamma-secretase cleaves Cntn1:Notch2 to release NICD2 (Mus musculus)
Authored
Orlic-Milacic, M  (2013-01-11)
Reviewed
Boyle, S  (2013-04-25)
Ilagan, MXG  (2013-04-25)
Created
Orlic-Milacic, M  (2013-01-07)