POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The EOMES gene is bound by POU5F1 (OCT4) (Boyer et al. 2005, Jin et al. 2007, Jung et al. 2010), SOX2 (Boyer et al. 2005), and NANOG (Boyer et al. 2005, Lister et al. 2009) in embryonic stem cells. POU5F1 (Babaie et al. 2007, Kunarso et al. 2010) and SOX2 (Teo et al. 2011) repress expression, however NANOG enhances expression (Teo et al. 2011). As inferred from mouse, EOMES is required for differentiation of mesoderm (Russ et al. 2000) and directly activates Mesp1, a regulator of cardiovascular differentiation (van den Ameele et al. 2012).
Literature References
PubMed ID Title Journal Year
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Thomson, JA, Nery, JR, Ye, Z, Pelizzola, M, Ruotti, V, Lister, R, Antosiewicz-Bourget, J, Tonti-Filippini, J, Edsall, L, Hawkins, RD, Lee, L, Ecker, JR, Dowen, RH, Hon, G, Ren, B, Ngo, QM, Stewart, R, Millar, AH

Nature 2009
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Ng, HH, Chan, YS, Bourque, G, Chia, NY, Hwang, C, Kunarso, G, Lu, X, Jeyakani, J

Nat. Genet. 2010
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Gifford, DK, Jaenisch, R, Lee, TI, Young, RA, Kumar, RM, Guenther, MG, Levine, SS, Boyer, LA, Jenner, RG, Cole, MF, Zucker, JP, Murray, HL, Johnstone, SE, Melton, DA

Cell 2005
10716450 Eomesodermin is required for mouse trophoblast development and mesoderm formation

Pearce, JJ, Nehls, MC, Russ, AP, Carlton, MB, Aparicio, SA, Evans, MJ, Surani, MA, Colledge, WH, Ryan, K, Wilson, V, Barton, SC, Wattler, S

Nature 2000
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Adjaye, J, Kahlem, P, Lehrach, H, Vilo, J, Peterson, H, Chavez, L, Jung, M

PLoS One 2010
21245162 Pluripotency factors regulate definitive endoderm specification through eomesodermin

Dunn, NR, Chng, Z, Trotter, MW, Vallier, L, Teo, AK, Ang, LT, Brown, S, Arnold, SJ, Robertson, EJ

Genes Dev. 2011
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Groth, D, Wruck, W, Greber, B, Lehrach, H, Brink, TC, Burdon, T, Herwig, R, Adjaye, J

Stem Cells 2007
22402664 Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin

Paulissen, C, Blanpain, C, Iacovino, M, Herpoel, A, Tiberi, L, Vanderhaeghen, P, Kyba, M, van den Ameele, J, Bondue, A

EMBO Rep. 2012
Cite Us!