POU5F1 (OCT4), SOX2, NANOG bind the EOMES promoter

Stable Identifier
R-HSA-2972949
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The EOMES gene is bound by POU5F1 (OCT4) (Boyer et al. 2005, Jin et al. 2007, Jung et al. 2010), SOX2 (Boyer et al. 2005), and NANOG (Boyer et al. 2005, Lister et al. 2009) in embryonic stem cells. POU5F1 (Babaie et al. 2007, Kunarso et al. 2010) and SOX2 (Teo et al. 2011) repress expression, however NANOG enhances expression (Teo et al. 2011). As inferred from mouse, EOMES is required for differentiation of mesoderm (Russ et al. 2000) and directly activates Mesp1, a regulator of cardiovascular differentiation (van den Ameele et al. 2012).

Literature References
PubMed ID Title Journal Year
20526341 Transposable elements have rewired the core regulatory network of human embryonic stem cells

Kunarso, G, Chia, NY, Jeyakani, J, Hwang, C, Lu, X, Chan, YS, Ng, HH, Bourque, G

Nat. Genet. 2010
19829295 Human DNA methylomes at base resolution show widespread epigenomic differences

Lister, R, Pelizzola, M, Dowen, RH, Hawkins, RD, Hon, G, Tonti-Filippini, J, Nery, JR, Lee, L, Ye, Z, Ngo, QM, Edsall, L, Antosiewicz-Bourget, J, Stewart, R, Ruotti, V, Millar, AH, Thomson, JA, Ren, B, Ecker, JR

Nature 2009
16153702 Core transcriptional regulatory circuitry in human embryonic stem cells

Boyer, LA, Lee, TI, Cole, MF, Johnstone, SE, Levine, SS, Zucker, JP, Guenther, MG, Kumar, RM, Murray, HL, Jenner, RG, Gifford, DK, Melton, DA, Jaenisch, R, Young, RA

Cell 2005
10716450 Eomesodermin is required for mouse trophoblast development and mesoderm formation

Russ, AP, Wattler, S, Colledge, WH, Aparicio, SA, Carlton, MB, Pearce, JJ, Barton, SC, Surani, MA, Ryan, K, Nehls, MC, Wilson, V, Evans, MJ

Nature 2000
20505756 A data integration approach to mapping OCT4 gene regulatory networks operative in embryonic stem cells and embryonal carcinoma cells

Jung, M, Peterson, H, Chavez, L, Kahlem, P, Lehrach, H, Vilo, J, Adjaye, J

PLoS One 2010
21245162 Pluripotency factors regulate definitive endoderm specification through eomesodermin

Teo, AK, Arnold, SJ, Trotter, MW, Brown, S, Ang, LT, Chng, Z, Robertson, EJ, Dunn, NR, Vallier, L

Genes Dev. 2011
17068183 Analysis of Oct4-dependent transcriptional networks regulating self-renewal and pluripotency in human embryonic stem cells

Babaie, Y, Herwig, R, Greber, B, Brink, TC, Wruck, W, Groth, D, Lehrach, H, Burdon, T, Adjaye, J

Stem Cells 2007
22402664 Eomesodermin induces Mesp1 expression and cardiac differentiation from embryonic stem cells in the absence of Activin

van den Ameele, J, Tiberi, L, Bondue, A, Paulissen, C, Herpoel, A, Iacovino, M, Kyba, M, Blanpain, C, Vanderhaeghen, P

EMBO Rep. 2012
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