Reactome | Activation of TAK1 complex bound to pUb-TRAF6

Schema > BlackBoxEvent > Entries

Activation of TAK1 complex bound to pUb-TRAF6 Show undefined attributes

catalystActivity	[CatalystActivity:10046376] protein serine/threonine kinase activity of DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10046378
displayName	Activation of TAK1 complex bound to pUb-TRAF6
eventOf	[Pathway:R-MMU-2871837] FCERI mediated NF-kB activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2730876] Phosphorylation of IKK-beta by TAK1 - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-2730900] Activation of TAK1 complex bound to pUb-TRAF6 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-2685689] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of TAK1 complex bound to pUb-TRAF6
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-2685689] DAG:p-5Y-PKC-theta:CBM oligomer:oligo-K63-poly Ub-TRAF6:TAK1:TAB1:TAB2/3 [plasma membrane]
precedingEvent	[Reaction:R-MMU-2730861] Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6 - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-2730900
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2871837] FCERI mediated NF-kB activation
(precedingEvent)	[Reaction:R-MMU-2730876] Phosphorylation of IKK-beta by TAK1
(inferredTo)	[BlackBoxEvent:R-HSA-2730900] Activation of TAK1 complex bound to pUb-TRAF6

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