Reactome | Phosphorylation of MEK7 by MEKK1

Phosphorylation of MEK7 by MEKK1

Stable Identifier

R-HSA-2730868

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MKK7 is activated by MEKK1 and the residues serine 271 and threonine 275 are the potential phosphorylation sites that are crucial for its kinase activity (phosphorylation sites are based on sequence alignment with MAP kinase kinase family members).

Literature References

PubMed ID	Title	Journal	Year
11306453	Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers Kim, HL, Vander Griend, DJ, Yang, X, Benson, DA, Dubauskas, Z, Yoshida, BA, Chekmareva, MA, Ichikawa, Y, Sokoloff, MH, Zhan, P, Karrison, T, Lin, A, Stadler, WM, Ichikawa, T, Rubin, MA, Rinker-Schaeffer, CW	Cancer Res.	2001
9639556	Differential activation of stress-activated protein kinase kinases SKK4/MKK7 and SKK1/MKK4 by the mixed-lineage kinase-2 and mitogen-activated protein kinase kinase (MKK) kinase-1 Cuenda, A, Dorow, DS	Biochem. J.	1998