Translocation of CaN:CaM:NFAT to nucleus

Stable Identifier
R-HSA-2730867
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Translocation of CaN:CaM:NFAT to nucleus
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Dephosphorylated NFAT-calcineurin (CaN) complex translocates to nucleus, where it activates transcription of several cytokine genes (e.g..IL2).

Literature References
PubMed ID Title Journal Year
11030334 Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity

Zhang, X, Rao, A, Viola, JP, Okamura, H, Hogan, PG, Tahiliani, M, Aramburu, J, García-Rodríguez, C, Qin, J, Raghavan, A

Mol Cell 2000
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Orthologous Events
Translocation of CaN:CaM:NFAT to nucleus (Bos taurus)
Translocation of CaN:CaM:NFAT to nucleus (Caenorhabditis elegans)
Translocation of CaN:CaM:NFAT to nucleus (Canis familiaris)
Translocation of CaN:CaM:NFAT to nucleus (Danio rerio)
Translocation of CaN:CaM:NFAT to nucleus (Drosophila melanogaster)
Translocation of CaN:CaM:NFAT to nucleus (Gallus gallus)
Translocation of CaN:CaM:NFAT to nucleus (Mus musculus)
Translocation of CaN:CaM:NFAT to nucleus (Rattus norvegicus)
Translocation of CaN:CaM:NFAT to nucleus (Sus scrofa)
Translocation of CaN:CaM:NFAT to nucleus (Xenopus tropicalis)
Authored
Niarakis, A  (2012-12-21)
Reviewed
Roncagalli, R  (2013-02-13)
Created
Garapati, P V  (2012-12-05)
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