CLCN4/5/6 exchange Cl- for H+

Stable Identifier
R-HSA-2730692
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endosome lumen, endosome membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CLCN4/5/6 exchange Cl- for H+
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The H+/Cl- exchange transporters CLCN4 (Kawasaki et al. 1999, Zdebik et al. 2008), CLCN5 (Zdebik et al. 2008) and CLCN6 (Neagoe et al. 2010) mediate the exchange of endosomal Cl- for cytosolic H+ across endosomal membranes, contributing to the acidification of endosomes.
Literature References
PubMed ID Title Journal Year
20466723 The late endosomal ClC-6 mediates proton/chloride countertransport in heterologous plasma membrane expression

Neagoe, I, Stauber, T, Fidzinski, P, Bergsdorf, EY, Jentsch, TJ

J. Biol. Chem. 2010
10564087 Identification of an acid-activated Cl(-) channel from human skeletal muscles

Kawasaki, M, Fukuma, T, Yamauchi, K, Sakamoto, H, Marumo, F, Sasaki, S

Am. J. Physiol. 1999
18063579 Determinants of anion-proton coupling in mammalian endosomal CLC proteins

Zdebik, AA, Zifarelli, G, Bergsdorf, EY, Soliani, P, Scheel, O, Jentsch, TJ, Pusch, M

J. Biol. Chem. 2008
Participants
Input
Output
Participates
as an event of
Catalyst Activity

antiporter activity of CLCN4/5/6 [endosome membrane]

Physical Entity
CLCN4/5/6 [endosome membrane] (Homo sapiens)
Activity
antiporter activity (GO:0015297)
Orthologous Events
CLCN4/5/6 exchange Cl- for H+ (Bos taurus)
CLCN4/5/6 exchange Cl- for H+ (Caenorhabditis elegans)
CLCN4/5/6 exchange Cl- for H+ (Canis familiaris)
CLCN4/5/6 exchange Cl- for H+ (Danio rerio)
CLCN4/5/6 exchange Cl- for H+ (Dictyostelium discoideum)
CLCN4/5/6 exchange Cl- for H+ (Drosophila melanogaster)
CLCN4/5/6 exchange Cl- for H+ (Gallus gallus)
CLCN4/5/6 exchange Cl- for H+ (Mus musculus)
CLCN4/5/6 exchange Cl- for H+ (Rattus norvegicus)
CLCN4/5/6 exchange Cl- for H+ (Saccharomyces cerevisiae)
CLCN4/5/6 exchange Cl- for H+ (Schizosaccharomyces pombe)
CLCN4/5/6 exchange Cl- for H+ (Sus scrofa)
CLCN4/5/6 exchange Cl- for H+ (Xenopus tropicalis)
Authored
Jassal, B  (2012-12-04)
Reviewed
He, L  (2013-01-28)
Created
Jassal, B  (2012-12-04)
Cite Us!