Reactome | SCNN channels transport extracellular Na+ to cytosol

SCNN channels transport extracellular Na+ to cytosol

Stable Identifier

R-HSA-2672334

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, cytosol, plasma membrane

Synonyms

Extracellular Na+ is transported to cytosol by SCNN channel

ReviewStatus

5/5

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SCNN channels transport extracellular Na+ to cytosol

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Amiloride-sensitive sodium channels (SCNNs, aka ENaCs, epithelial Na+ channels, non voltage-gated sodium channels) belong to the epithelial Na+ channel/degenerin (ENaC/DEG) protein family and mediate the transport of Na+ (and associated water) through the apical membrane of epithelial cells in kidney, colon and lungs. This makes SCNNs important determinants of systemic blood pressure. The physiological activator for SCNNs is unknown but as they belong in the same family as acid-sensitive ion channels (ASICs, which are mediated by protons), these may also be the activating ligands for SCNNs. SCNNs are probable heterotrimers comprising an alpha (or interchangeable delta subunit), beta and gamma subunit (Horisberger 1998).

Literature References

PubMed ID	Title	Journal	Year
9719863	Amiloride-sensitive Na channels Horisberger, JD	Curr. Opin. Cell Biol.	1998
28790369	Arginyl dipeptides increase the frequency of NaCl-elicited responses via epithelial sodium channel alpha and delta subunits in cultured human fungiform taste papillae cells Xu, JJ, Spielman, AI, Ozdener, MH, Garcia-Blanco, A, Chung, HY, Bachmanov, AA, Elkaddi, N	Sci Rep	2017