SCNN channels transport extracellular Na+ to cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
Extracellular Na+ is transported to cytosol by SCNN channel
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Amiloride-sensitive sodium channels (SCNNs, aka ENaCs, epithelial Na+ channels, non voltage-gated sodium channels) belong to the epithelial Na+ channel/degenerin (ENaC/DEG) protein family and mediate the transport of Na+ (and associated water) through the apical membrane of epithelial cells in kidney, colon and lungs. This makes SCNNs important determinants of systemic blood pressure. The physiological activator for SCNNs is unknown but as they belong in the same family as acid-sensitive ion channels (ASICs, which are mediated by protons), these may also be the activating ligands for SCNNs. SCNNs are probable heterotrimers comprising an alpha (or interchangeable delta subunit), beta and gamma subunit (Horisberger 1998).

Literature References
PubMed ID Title Journal Year
28790369 Arginyl dipeptides increase the frequency of NaCl-elicited responses via epithelial sodium channel alpha and delta subunits in cultured human fungiform taste papillae cells

Xu, JJ, Elkaddi, N, Garcia-Blanco, A, Spielman, AI, Bachmanov, AA, Chung, HY, Ozdener, MH

Sci Rep 2017
9719863 Amiloride-sensitive Na channels

Horisberger, JD

Curr. Opin. Cell Biol. 1998
Catalyst Activity

ligand-gated sodium channel activity of SCNN channels [plasma membrane]

This event is regulated
Negatively by
Orthologous Events
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