Reactome | SCNN channels transport extracellular Na+ to cytosol

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SCNN channels transport extracellular Na+ to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10505001] ligand-gated sodium channel activity of SCNN channels [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10505003
displayName	SCNN channels transport extracellular Na+ to cytosol
eventOf	[Pathway:R-SSC-9730628] Sensory perception of salty taste - Sus scrofa [Pathway:R-SSC-2672351] Stimuli-sensing channels - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2672334] SCNN channels transport extracellular Na+ to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SCNN channels transport extracellular Na+ to cytosol Extracellular Na+ is transported to cytosol by SCNN channel
output	[SimpleEntity:R-ALL-83910] Na+ [cytosol]
regulatedBy	[NegativeRegulation:R-HSA-2672371] Negative regulation by 'amiloride [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-2672334
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-9730628] Sensory perception of salty taste [Pathway:R-SSC-2672351] Stimuli-sensing channels
(inferredTo)	[Reaction:R-HSA-2672334] SCNN channels transport extracellular Na+ to cytosol

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