Reactome | Calcium Influx through Voltage-gated Calcium Channels

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Calcium Influx through Voltage-gated Calcium Channels Show undefined attributes

authored	[InstanceEdit:265162] May, B, 2008-04-15 08:41:29
catalystActivity	[CatalystActivity:265625] voltage-gated calcium channel activity of Voltage-gated Calcium Channels (pancreatic beta cell) [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:265678] May, B, 2008-04-20 07:49:26
crossReference	[DatabaseIdentifier:12667421] RHEA:29671
dbId	265645
displayName	Calcium Influx through Voltage-gated Calcium Channels
edited	[InstanceEdit:392539] D'Eustachio, P, 2009-03-06 11:49:32 [InstanceEdit:391171] May, B, 2009-02-12 22:40:35
eventOf	[Pathway:R-HSA-422356] Regulation of insulin secretion - Homo sapiens
figure	[Figure:266138] /figures/VGCalciumChannel.jpg
followingEvent	[BlackBoxEvent:R-HSA-265166] Exocytosis of Insulin - Homo sapiens
input	[SimpleEntity:R-ALL-74112] Ca2+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:264707] Signals and pools underlying biphasic insulin secretion [LiteratureReference:264711] The role of voltage-gated calcium channels in pancreatic beta-cell physiology and pathophysiology [LiteratureReference:264705] Beta-cell CaV channel regulation in physiology and pathophysiology [LiteratureReference:264262] Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion [LiteratureReference:264712] A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells [LiteratureReference:264719] Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells [LiteratureReference:445905] Cloning of the alpha 1 subunit of a voltage-dependent calcium channel expressed in pancreatic beta cells [LiteratureReference:445918] Voltage-operated calcium channel heterogeneity in pancreatic beta cells: physiopathological implications [LiteratureReference:445907] Immunohistochemical detection of alpha1E voltage-gated Ca(2+) channel isoforms in cerebellum, INS-1 cells, and neuroendocrine cells of the digestive system [LiteratureReference:445914] Modal gating of human CaV2.1 (P/Q-type) calcium channels: I. The slow and the fast gating modes and their modulation by beta subunits [LiteratureReference:445915] The role of distal S6 hydrophobic residues in the voltage-dependent gating of CaV2.3 channels
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Calcium Influx through Voltage-gated Calcium Channels
orthologousEvent	[Reaction:R-CEL-265645] Calcium Influx through Voltage-gated Calcium Channels - Caenorhabditis elegans [Reaction:R-DME-265645] Calcium Influx through Voltage-gated Calcium Channels - Drosophila melanogaster [Reaction:R-GGA-265645] Calcium Influx through Voltage-gated Calcium Channels - Gallus gallus [Reaction:R-SSC-265645] Calcium Influx through Voltage-gated Calcium Channels - Sus scrofa [Reaction:R-BTA-265645] Calcium Influx through Voltage-gated Calcium Channels - Bos taurus [Reaction:R-CFA-265645] Calcium Influx through Voltage-gated Calcium Channels - Canis familiaris [Reaction:R-RNO-265645] Calcium Influx through Voltage-gated Calcium Channels - Rattus norvegicus [Reaction:R-MMU-265645] Calcium Influx through Voltage-gated Calcium Channels - Mus musculus
output	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
precedingEvent	[Reaction:R-HSA-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Homo sapiens [BlackBoxEvent:R-HSA-381713] Potassium voltage-gated channels close in reponse to PKA - Homo sapiens
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422557] Gillespie, ME, 2009-06-02 00:59:01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-265645
summation	[Summation:265720] Voltage-gated calcium channels respond to a change in voltag...
updateTrackers	[UpdateTracker:9791358] Update Tracker - [Reaction:265645] Calcium Influx through Voltage-gated Calcium Channels - v31:[add_removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9791358] Update Tracker - [Reaction:265645] Calcium Influx through Voltage-gated Calcium Channels - v31:[add_removeLiteratureReference]
(precedingEvent)	[BlackBoxEvent:R-HSA-265166] Exocytosis of Insulin
(hasEvent)	[Pathway:R-HSA-422356] Regulation of insulin secretion

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