Reactome | KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel

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KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel Show undefined attributes

authored	[InstanceEdit:265162] May, B, 2008-04-15 08:41:29
catalystActivity	[CatalystActivity:264517] ATP binding activity of KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:265678] May, B, 2008-04-20 07:49:26
dbId	265682
diseaseReaction	[FailedReaction:R-HSA-5683113] Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia - Homo sapiens
displayName	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel
edited	[InstanceEdit:392539] D'Eustachio, P, 2009-03-06 11:49:32 [InstanceEdit:391171] May, B, 2009-02-12 22:40:35
eventOf	[Pathway:R-HSA-422356] Regulation of insulin secretion - Homo sapiens
followingEvent	[Reaction:R-HSA-265645] Calcium Influx through Voltage-gated Calcium Channels - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-265734] KCNJ11 tetramer:ABCC8:Mg2+:ADP tetramer [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:445976] A rare mutation in ABCC8/SUR1 leading to altered ATP-sensitive K+ channel activity and beta-cell glucose sensing is associated with type 2 diabetes in adults [LiteratureReference:445980] Coexpression of the type 2 diabetes susceptibility gene variants KCNJ11 E23K and ABCC8 S1369A alter the ATP and sulfonylurea sensitivities of the ATP-sensitive K(+) channel [LiteratureReference:445969] Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations [LiteratureReference:445977] A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels [LiteratureReference:445951] Two regions of sulfonylurea receptor specify the spontaneous bursting and ATP inhibition of KATP channel isoforms [LiteratureReference:445966] Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y [LiteratureReference:445961] Functional analysis of six Kir6.2 (KCNJ11) mutations causing neonatal diabetes [LiteratureReference:445958] The structure and function of the ATP-sensitive K+ channel in insulin-secreting pancreatic beta-cells [LiteratureReference:445953] Low levels of glucose transporters and K+ATP channels in human pancreatic beta cells early in development [LiteratureReference:264728] Minireview: implication of mitochondria in insulin secretion and action [LiteratureReference:264726] Triggering and amplifying pathways of regulation of insulin secretion by glucose [LiteratureReference:264727] Action potentials and insulin secretion: new insights into the role of Kv channels [LiteratureReference:264719] Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells [LiteratureReference:266004] Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice [LiteratureReference:1296246] Inwardly rectifying potassium channels: their structure, function, and physiological roles
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel Closing of Inward Rectifying, ATP-sensitive Potassium Channels (KATP channels)
orthologousEvent	[Reaction:R-MMU-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Mus musculus [Reaction:R-RNO-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Rattus norvegicus [Reaction:R-CFA-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Canis familiaris [Reaction:R-BTA-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Bos taurus [Reaction:R-SSC-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Sus scrofa [Reaction:R-DRE-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Danio rerio [Reaction:R-XTR-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Xenopus tropicalis [Reaction:R-GGA-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Gallus gallus [Reaction:R-DME-265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - Drosophila melanogaster
output	[Complex:R-HSA-265746] KCNJ11:ATP tetramer:ABCC8 tetramer [plasma membrane] 4 × [Complex:R-ALL-6790050] Mg2+:ADP [cytosol]
precedingEvent	[Reaction:R-HSA-381707] PKA:AKAP79:IQGAP1 complex dissociates to active PKA subunits in response to cAMP - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-422332] Positive regulation by 'PKA catalytic subunit [cytosol]' [PositiveRegulation:R-HSA-446922] Positive regulation by 'RAPGEF4:cAMP Complex [plasma membrane]' [PositiveRegulation:R-HSA-446924] Positive regulation by 'RAPGEF3:cAMP complex [plasma membrane]' [NegativeRegulation:R-HSA-5339572] Negative regulation by 'Zn2+ [extracellular region]' [PositiveRegulation:R-HSA-5683249] Positive regulation by 'Glc [cytosol]'
regulationReference	[RegulationReference:9641324] Positive regulation by 'RAPGEF3:cAMP complex [plasma membrane]' Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells [RegulationReference:9641757] Positive regulation by 'RAPGEF4:cAMP Complex [plasma membrane]' Role of the cAMP sensor Epac as a determinant of KATP channel ATP sensitivity in human pancreatic beta-cells and rat INS-1 cells [RegulationReference:9641802] Positive regulation by 'PKA catalytic subunit [cytosol]' Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism
releaseDate	2009-04-01
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:422557] Gillespie, ME, 2009-06-02 00:59:01
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-265682
summation	[Summation:265570] The beta-cell ATP-sensitive potassium channel (KATP channel)... [Summation:446925] Epac2 is activated by binding cAMP, forms a complex with inw... [Summation:381715] Activated PKA promotes the closing of inward rectifying pota... [Summation:446926] Epac1 is activated by binding cAMP, forms a complex with inw...
updateTrackers	[UpdateTracker:9791354] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v31:[addRegulator, add_removeLiteratureReference] [UpdateTracker:9786576] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v49:[addRegulator] [UpdateTracker:9784638] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v53:[addRegulator, modifyText] [UpdateTracker:9775947] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v78:[addSummation] [UpdateTracker:9791482] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v29:[addRegulator] [UpdateTracker:9784099] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v54:[addLiteratureReference, addOutput, modifyText]

Referrals

(precedingEvent)	[Reaction:R-HSA-265645] Calcium Influx through Voltage-gated Calcium Channels
(hasEvent)	[Pathway:R-HSA-422356] Regulation of insulin secretion
(normalReaction)	[FailedReaction:R-HSA-5683113] Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia
(updatedInstance)	[UpdateTracker:9791354] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v31:[addRegulator, add_removeLiteratureReference] [UpdateTracker:9786576] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v49:[addRegulator] [UpdateTracker:9784638] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v53:[addRegulator, modifyText] [UpdateTracker:9775947] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v78:[addSummation] [UpdateTracker:9791482] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v29:[addRegulator] [UpdateTracker:9784099] Update Tracker - [Reaction:265682] KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel - v54:[addLiteratureReference, addOutput, modifyText]

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