Reactome | Exocytosis of Insulin

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Exocytosis of Insulin Show undefined attributes

authored	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
catalystActivity	[CatalystActivity:266281] calcium ion binding activity of Synaptotagmin V/IX [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:216887] May, B, 2008-03-24 09:01:13
dbId	216883
displayName	Exocytosis of Insulin
edited	[InstanceEdit:445578] May, B, 2009-10-31
input	[DefinedSet:R-MMU-216653] C peptide [secretory granule lumen] [SimpleEntity:R-ALL-74016] Ca2+ [cytosol] [Complex:R-MMU-216790] Insulin:Zinc:Calcium [secretory granule lumen] [EntityWithAccessionedSequence:R-MMU-216885] Snap25 (isoform 1) [plasma membrane] [EntityWithAccessionedSequence:R-MMU-216884] Syntaxin-1A [plasma membrane] [EntityWithAccessionedSequence:R-MMU-216889] VAMP2 (Synaptobrevin-2) (in mature granule membrane) [secretory granule membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:264297] Molecular determinants of regulated exocytosis [LiteratureReference:264263] Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion [LiteratureReference:264260] Insulin vesicle release: walk, kiss, pause ... then run [LiteratureReference:264310] Insulin secretion by 'kiss-and-run' exocytosis in clonal pancreatic islet beta-cells [LiteratureReference:264300] Insulin secretion: a high-affinity Ca2+ sensor after all? [LiteratureReference:264262] Triggering and augmentation mechanisms, granule pools, and biphasic insulin secretion [LiteratureReference:445588] Expression and localisation of synaptotagmin isoforms in endocrine beta-cells: their function in insulin exocytosis [LiteratureReference:445581] Identification of the docked granule pool responsible for the first phase of glucose-stimulated insulin secretion [LiteratureReference:445590] Munc18c depletion selectively impairs the sustained phase of insulin release [LiteratureReference:264303] Imaging analysis reveals mechanistic differences between first- and second-phase insulin exocytosis [LiteratureReference:445596] Antibody inhibition of synaptosomal protein of 25 kDa (SNAP-25) and syntaxin 1 reduces rapid exocytosis in insulin-secreting cells [LiteratureReference:264322] Syntaxin 4 facilitates biphasic glucose-stimulated insulin secretion from pancreatic beta-cells [LiteratureReference:445597] Site of docking and fusion of insulin secretory granules in live MIN6 beta cells analyzed by TAT-conjugated anti-syntaxin 1 antibody and total internal reflection fluorescence microscopy [LiteratureReference:445582] Role of syntaxin in mouse pancreatic beta cells [LiteratureReference:445595] A direct interaction between Cdc42 and vesicle-associated membrane protein 2 regulates SNARE-dependent insulin exocytosis
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Exocytosis of Insulin
orthologousEvent	[BlackBoxEvent:R-HSA-265166] Exocytosis of Insulin - Homo sapiens
output	[DefinedSet:R-MMU-266285] C-peptide [extracellular region] [Complex:R-MMU-266279] Insulin:Zinc:Calcium [extracellular region] [EntityWithAccessionedSequence:R-MMU-216888] Munc-18a [plasma membrane] [Complex:R-MMU-266278] SNARE Complex [plasma membrane]
releaseDate	2010-06-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:445578] May, B, 2009-10-31
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-216883
summation	[Summation:264206] Exocytosis of insulin-zinc granules occurs by the calcium-de...
updateTrackers	[UpdateTracker:9864329] Update Tracker - [BlackBoxEvent:216883] Exocytosis of Insulin - v88:[modifyText] [UpdateTracker:9779975] Update Tracker - [BlackBoxEvent:216883] Exocytosis of Insulin - v64:[removeCatalystActivity]

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(updatedInstance)

[UpdateTracker:9864329] Update Tracker - [BlackBoxEvent:216883] Exocytosis of Insulin - v88:[modifyText]
[UpdateTracker:9779975] Update Tracker - [BlackBoxEvent:216883] Exocytosis of Insulin - v64:[removeCatalystActivity]

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