Reactome | JAK2 Phosphoryates STAT3 in Response to Leptin

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JAK2 Phosphoryates STAT3 in Response to Leptin Show undefined attributes

authored	[InstanceEdit:2586547] May, B, 2012-11-15
catalystActivity	[CatalystActivity:2671840] protein tyrosine kinase activity of LEP:p-LEPR:p-JAK2:STAT3 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2671863] May, B, 2012-11-26
dbId	2671850
displayName	JAK2 Phosphoryates STAT3 in Response to Leptin
edited	[InstanceEdit:2671737] May, B, 2012-11-24
eventOf	[Pathway:R-HSA-2586552] Signaling by Leptin - Homo sapiens
followingEvent	[Reaction:R-HSA-2671839] Phosphorylated STAT3 Dissociates from Leptin Receptor - Homo sapiens
inferredFrom	[Reaction:R-MMU-2671836] Jak2 Phosphorylates Stat3 in Response to Leptin - Mus musculus
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2671864] LEP:p-LEPR:p-JAK2:STAT3 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2672287] Divergent signaling capacities of the long and short isoforms of the leptin receptor
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 Phosphoryates STAT3 in Response to Leptin
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-2671874] LEP:p-LEPR:p-JAK2:p-STAT3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-2671868] Phosphorylated LEPR Binds STAT3 - Homo sapiens
releaseDate	2013-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:4420239] Scherer, Thomas, 2013-08-31 [InstanceEdit:4789050] Gonzalez-Perez, Ruben Rene, 2013-10-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2671850
summation	[Summation:2672262] Phosphorylated JAK2 in the LEP:LEPR:JAK2:STAT3 complex phosp...

Referrals

(hasEvent)	[Pathway:R-HSA-2586552] Signaling by Leptin
(precedingEvent)	[Reaction:R-HSA-2671839] Phosphorylated STAT3 Dissociates from Leptin Receptor
(inferredTo)	[Reaction:R-MMU-2671836] Jak2 Phosphorylates Stat3 in Response to Leptin

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