Reactome | MMP14 (MT1-MMP) can degrade fibronectin (Shi & Sottile 2011;...

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created	[InstanceEdit:2533918] Jupe, S, 2012-10-22
dbId	2533849
displayName	MMP14 (MT1-MMP) can degrade fibronectin (Shi & Sottile 2011;...
literatureReference	[LiteratureReference:2485117] MT1-MMP regulates the turnover and endocytosis of extracellular matrix fibronectin [LiteratureReference:2485114] Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions [LiteratureReference:2533919] The low density lipoprotein receptor-related protein mediates fibronectin catabolism and inhibits fibronectin accumulation on cell surfaces [LiteratureReference:2533832] Fibronectin matrix turnover occurs through a caveolin-1-dependent process [LiteratureReference:9863898] Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly to promote cell motility
modified	[InstanceEdit:9863900] Shamovsky, Veronica, 2024-03-05
schemaClass	Summation
text	MMP14 (MT1-MMP) can degrade fibronectin (Shi & Sottile 2011; Takino et al. 2011). Studies have shown that fibronectin turnover is not prevented by protease inhibitors (Sottile & Hocking 2002) and suggest that caveolin-1-mediated endocytosis and intracellular degradation are involved (Salicioni et al. 2002, Sottile & Chandler 2004).

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