Reactome | Phosphorylated condensin I promotes condensation of prometaphase chromosomes

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Phosphorylated condensin I promotes condensation of prometaphase chromosomes Show undefined attributes

authored	[InstanceEdit:2525913] Orlic-Milacic, M, 2012-10-12
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2520885] Orlic-Milacic, M, 2012-10-11
dbId	2520883
displayName	Phosphorylated condensin I promotes condensation of prometaphase chromosomes
edited	[InstanceEdit:2555383] Matthews, L, 2012-10-18 [InstanceEdit:2532796] D'Eustachio, P, 2012-10-19
eventOf	[Pathway:R-HSA-2514853] Condensation of Prometaphase Chromosomes - Homo sapiens
input	[OtherEntity:R-ALL-2520882] Condensed prophase chromosomes [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2294599] The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II [LiteratureReference:2514841] Chromosome condensation by a human condensin complex in Xenopus egg extracts [LiteratureReference:2514845] Phosphorylation and activation of 13S condensin by Cdc2 in vitro [LiteratureReference:2520895] Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells [LiteratureReference:2514849] Negative regulation of condensin I by CK2-mediated phosphorylation [LiteratureReference:2520892] Distinct functions of condensin I and II in mitotic chromosome assembly [LiteratureReference:2520890] Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes [LiteratureReference:2525912] Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis [LiteratureReference:2525920] Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated condensin I promotes condensation of prometaphase chromosomes
output	[OtherEntity:R-ALL-2520884] Condensed prometaphase chromosomes [cytosol]
precedingEvent	[Reaction:R-HSA-2514854] CDK1 phosphorylates condensin I - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-2520881] Positive regulation by 'CDK1 Phosphorylated Condensin I [cytosol]'
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2580340] Anonymous, 2012-11-12
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2520883
summation	[Summation:2520897] While condensin II complex (consisting of subunits SMC2, SMC...

Referrals

(hasEvent)

[Pathway:R-HSA-2514853] Condensation of Prometaphase Chromosomes

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