Reactome | Condensation of Prometaphase Chromosomes

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Condensation of Prometaphase Chromosomes Show undefined attributes

authored	[InstanceEdit:2525913] Orlic-Milacic, M, 2012-10-12
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2514846] Orlic-Milacic, M, 2012-10-10
dbId	2514853
displayName	Condensation of Prometaphase Chromosomes
doi	10.3180/REACT_150260.1
edited	[InstanceEdit:2555383] Matthews, L, 2012-10-18 [InstanceEdit:2532796] D'Eustachio, P, 2012-10-19
eventOf	[Pathway:R-HSA-68877] Mitotic Prometaphase - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18551] mitotic chromosome condensation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2529020] CK2 phosphorylates condensin I subunits - Homo sapiens [Reaction:R-HSA-2529015] Dephosphorylation of CK2-modified condensin I - Homo sapiens [Reaction:R-HSA-2514854] CDK1 phosphorylates condensin I - Homo sapiens [BlackBoxEvent:R-HSA-2520883] Phosphorylated condensin I promotes condensation of prometaphase chromosomes - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2523110] A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro [LiteratureReference:2523113] Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein [LiteratureReference:2523112] ATP-dependent positive supercoiling of DNA by 13S condensin: a biochemical implication for chromosome condensation [LiteratureReference:2514841] Chromosome condensation by a human condensin complex in Xenopus egg extracts [LiteratureReference:2514855] Cell cycle-dependent phosphorylation, nuclear localization, and activation of human condensin [LiteratureReference:2514845] Phosphorylation and activation of 13S condensin by Cdc2 in vitro [LiteratureReference:2514849] Negative regulation of condensin I by CK2-mediated phosphorylation [LiteratureReference:2520895] Spatial and temporal regulation of Condensins I and II in mitotic chromosome assembly in human cells [LiteratureReference:2520892] Distinct functions of condensin I and II in mitotic chromosome assembly [LiteratureReference:2520890] Aurora B controls the association of condensin I but not condensin II with mitotic chromosomes [LiteratureReference:2525912] Phosphorylation of CAP-G is required for its chromosomal DNA localization during mitosis [LiteratureReference:2525920] Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity [LiteratureReference:2525908] Three-step model for condensin activation during mitotic chromosome condensation [LiteratureReference:2581435] Lysine acetylation targets protein complexes and co-regulates major cellular functions [LiteratureReference:2581448] ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage [LiteratureReference:2581446] The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Condensation of Prometaphase Chromosomes
orthologousEvent	[Pathway:R-BTA-2514853] Condensation of Prometaphase Chromosomes - Bos taurus [Pathway:R-SCE-2514853] Condensation of Prometaphase Chromosomes - Saccharomyces cerevisiae [Pathway:R-SPO-2514853] Condensation of Prometaphase Chromosomes - Schizosaccharomyces pombe [Pathway:R-DDI-2514853] Condensation of Prometaphase Chromosomes - Dictyostelium discoideum [Pathway:R-DME-2514853] Condensation of Prometaphase Chromosomes - Drosophila melanogaster [Pathway:R-GGA-2514853] Condensation of Prometaphase Chromosomes - Gallus gallus [Pathway:R-DRE-2514853] Condensation of Prometaphase Chromosomes - Danio rerio [Pathway:R-SSC-2514853] Condensation of Prometaphase Chromosomes - Sus scrofa [Pathway:R-CFA-2514853] Condensation of Prometaphase Chromosomes - Canis familiaris [Pathway:R-RNO-2514853] Condensation of Prometaphase Chromosomes - Rattus norvegicus [Pathway:R-MMU-2514853] Condensation of Prometaphase Chromosomes - Mus musculus
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2580340] Anonymous, 2012-11-12
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2514853
summation	[Summation:2520876] The condensin I complex is evolutionarily conserved and cons...

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(hasEvent)

[Pathway:R-HSA-68877] Mitotic Prometaphase

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