Reactome | Establishment of Sister Chromatid Cohesion

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Establishment of Sister Chromatid Cohesion Show undefined attributes

authored	[InstanceEdit:2500295] Orlic-Milacic, M, 2012-10-02
compartment	[Compartment:1598585] chromosome [Compartment:81347] chromosome, centromeric region [Compartment:7660] nucleoplasm
created	[InstanceEdit:2468054] Orlic-Milacic, M, 2012-09-13
dbId	2468052
displayName	Establishment of Sister Chromatid Cohesion
edited	[InstanceEdit:2555380] Matthews, L, 2012-10-05 [InstanceEdit:2555378] Gillespie, ME, 2012-10-05
eventOf	[Pathway:R-HSA-69242] S Phase - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:18485] sister chromatid cohesion
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-2468039] Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2 - Homo sapiens [Reaction:R-HSA-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Homo sapiens [Reaction:R-HSA-2468041] CDCA5 (Sororin) enables cohesion of sister chromosomal arms - Homo sapiens [Reaction:R-HSA-2473151] CDCA5 (Sororin) enables cohesion of sister centromeres - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2013-03-31
literatureReference	[LiteratureReference:2485074] Live-cell imaging reveals a stable cohesin-chromatin interaction after but not before DNA replication [LiteratureReference:2485068] Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates [LiteratureReference:2485011] Sororin mediates sister chromatid cohesion by antagonizing Wapl [LiteratureReference:2485017] Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion [LiteratureReference:2485026] Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast [LiteratureReference:2485036] Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin
maxDepth	2
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Establishment of Sister Chromatid Cohesion
orthologousEvent	[Pathway:R-SCE-2468052] Establishment of Sister Chromatid Cohesion - Saccharomyces cerevisiae [Pathway:R-DDI-2468052] Establishment of Sister Chromatid Cohesion - Dictyostelium discoideum [Pathway:R-CEL-2468052] Establishment of Sister Chromatid Cohesion - Caenorhabditis elegans [Pathway:R-DME-2468052] Establishment of Sister Chromatid Cohesion - Drosophila melanogaster [Pathway:R-GGA-2468052] Establishment of Sister Chromatid Cohesion - Gallus gallus [Pathway:R-DRE-2468052] Establishment of Sister Chromatid Cohesion - Danio rerio [Pathway:R-SSC-2468052] Establishment of Sister Chromatid Cohesion - Sus scrofa [Pathway:R-BTA-2468052] Establishment of Sister Chromatid Cohesion - Bos taurus [Pathway:R-CFA-2468052] Establishment of Sister Chromatid Cohesion - Canis familiaris [Pathway:R-RNO-2468052] Establishment of Sister Chromatid Cohesion - Rattus norvegicus [Pathway:R-MMU-2468052] Establishment of Sister Chromatid Cohesion - Mus musculus
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2550413] Zhang, Nenggang, 2012-10-22 [InstanceEdit:3110247] Watanabe, Yoshinori, 2012-11-20 [InstanceEdit:3110251] Tanno, Yuji, 2012-11-20
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-2468052
summation	[Summation:2485075] The cohesin complex loads onto chromatin in telophase, but i...
updateTrackers	[UpdateTracker:9787592] Update Tracker - [Pathway:2468052] Establishment of Sister Chromatid Cohesion - v44:[modifyText, updateContainedRLE]

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(updatedInstance)	[UpdateTracker:9787592] Update Tracker - [Pathway:2468052] Establishment of Sister Chromatid Cohesion - v44:[modifyText, updateContainedRLE]
(hasEvent)	[Pathway:R-HSA-69242] S Phase

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