Reactome | Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2

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Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 Show undefined attributes

authored	[InstanceEdit:2500295] Orlic-Milacic, M, 2012-10-02
catalystActivity	[CatalystActivity:2468053] N-acetyltransferase activity of ESCO [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:81347] chromosome, centromeric region
created	[InstanceEdit:2473150] Orlic-Milacic, M, 2012-09-21
dbId	2473152
displayName	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
edited	[InstanceEdit:2555380] Matthews, L, 2012-10-05 [InstanceEdit:2555378] Gillespie, ME, 2012-10-05
eventOf	[Pathway:R-HSA-2468052] Establishment of Sister Chromatid Cohesion - Homo sapiens
followingEvent	[Reaction:R-HSA-2473151] CDCA5 (Sororin) enables cohesion of sister centromeres - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [Complex:R-HSA-2545177] Cohesin:PDS5:WAPAL:Centromere [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2485036] Cohesin acetyltransferase Esco2 is a cell viability factor and is required for cohesion in pericentric heterochromatin [LiteratureReference:2485026] Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast [LiteratureReference:2485017] Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion [LiteratureReference:2485020] Roberts syndrome is caused by mutations in ESCO2, a human homolog of yeast ECO1 that is essential for the establishment of sister chromatid cohesion [LiteratureReference:2485052] Roberts syndrome: a review of 100 cases and a new rating system for severity [LiteratureReference:2485042] The molecular mechanism underlying Roberts syndrome involves loss of ESCO2 acetyltransferase activity
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2
orthologousEvent	[Reaction:R-SCE-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Saccharomyces cerevisiae [Reaction:R-DDI-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Dictyostelium discoideum [Reaction:R-CEL-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Caenorhabditis elegans [Reaction:R-DME-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Drosophila melanogaster [Reaction:R-GGA-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Gallus gallus [Reaction:R-DRE-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Danio rerio [Reaction:R-SSC-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Sus scrofa [Reaction:R-BTA-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Bos taurus [Reaction:R-CFA-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Canis familiaris [Reaction:R-RNO-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Rattus norvegicus [Reaction:R-MMU-2473152] Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2 - Mus musculus
output	[Complex:R-HSA-2473149] Ac-Cohesin:PDS5:WAPAL:Centromere [nucleoplasm] 2 × [SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2550413] Zhang, Nenggang, 2012-10-22 [InstanceEdit:3110247] Watanabe, Yoshinori, 2012-11-20 [InstanceEdit:3110251] Tanno, Yuji, 2012-11-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2473152
summation	[Summation:2485048] Acetyltransferases ESCO1 and ESCO2 are homologs of the S. ce...

Referrals

(precedingEvent)	[Reaction:R-HSA-2473151] CDCA5 (Sororin) enables cohesion of sister centromeres
(hasEvent)	[Pathway:R-HSA-2468052] Establishment of Sister Chromatid Cohesion

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