Reactome | RPE65 isomero-hydrolyses atREs to 11cROL

RPE65 isomero-hydrolyses atREs to 11cROL

Stable Identifier

R-HSA-2453833

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, lipid droplet, plasma membrane

Synonyms

Retinoid isomerohydrolase isomero-hydrolyses retinyl esters to 11-cis-retinol

ReviewStatus

5/5

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RPE65 isomero-hydrolyses atREs to 11cROL

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All-trans-retinol esters (atREs) serve as substrates for retinoid isomerohydrolase (RPE65), located in retinal pigment epithelium (RPE) cells. RPE65 hydrolyses atREs to 11-cis-retinol (11cROL), thus performing an isomerase activity as well as hydrolysis. RPE65 is membrane-bound, this being dependent on the palmitylation of the residue Cys-112 (Takahashi et al. 2009). RPE65 normally undergoes a light-dependent translocation to become more concentrated in the central region of RPE cells. This translocation requires Unconventional myosin-VIIa (MYO7A or USH1B) (Lopes et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
19049981	Identification of a novel palmitylation site essential for membrane association and isomerohydrolase activity of RPE65 Ma, JX, Takahashi, Y, Ablonczy, Z, Moiseyev, G, Chen, Y, Crouch, RK	J. Biol. Chem.	2009
21493626	The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65 Welch, DL, Radu, RA, Aleman, TS, Gibbs, D, Williams, DS, Jacobson, SG, Lopes, VS, Steel, KP, Libby, RT, Lillo, C	Hum. Mol. Genet.	2011