Reactome | RPE65 isomero-hydrolyses atREs to 11cROL

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RPE65 isomero-hydrolyses atREs to 11cROL Show undefined attributes

catalystActivity	[CatalystActivity:10690730] all-trans-retinyl-palmitate hydrolase, 11-cis retinol forming activity of RPE65 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13977] lipid droplet [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10690732
displayName	RPE65 isomero-hydrolyses atREs to 11cROL
eventOf	[Pathway:R-XTR-2453902] The canonical retinoid cycle in rods (twilight vision) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-2454264] 11cROL binds to RLBP1 to form RLBP1:11cROL - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-2453833] RPE65 isomero-hydrolyses atREs to 11cROL - Homo sapiens
input	[SimpleEntity:R-ALL-9982476] atRE [lipid droplet] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RPE65 isomero-hydrolyses atREs to 11cROL Retinoid isomerohydrolase isomero-hydrolyses retinyl esters to 11-cis-retinol
output	[SimpleEntity:R-ALL-30927] 11cROL [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-9982478] RCOO- [lipid droplet]
precedingEvent	[Reaction:R-XTR-2453855] LRAT esterifies RBP1:atROL and FACYLs to atREs - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2453833
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2453902] The canonical retinoid cycle in rods (twilight vision)
(precedingEvent)	[Reaction:R-XTR-2454264] 11cROL binds to RLBP1 to form RLBP1:11cROL
(inferredTo)	[Reaction:R-HSA-2453833] RPE65 isomero-hydrolyses atREs to 11cROL

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