Reactome | Activated PI3K phosphorylates phosphatidylinositol (PI) 4-ph...

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created	[InstanceEdit:2424330] Garapati, P V, 2012-07-23
dbId	2424321
displayName	Activated PI3K phosphorylates phosphatidylinositol (PI) 4-ph...
literatureReference	[LiteratureReference:191524] Activation of phospholipase C gamma by PI 3-kinase-induced PH domain-mediated membrane targeting [LiteratureReference:437166] Signalling through the lipid products of phosphoinositide-3-OH kinase [LiteratureReference:2424358] Vav links antigen-receptor signaling to the actin cytoskeleton
schemaClass	Summation
text	Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. Products of PI3K are involved in the regulation of PLC-gamma 1 and VAV activation. The PH domain of PLC-gamma 1 binds to PIP3 and is targeted to the membrane. PIP3 binds to the PH domain of VAV2/VAV3 and increases it activity and PI3K may also strongly stimulate VAV activity by converting an inhibitory regulator VAV to an activator (Toker & Cantley 1997, Fischer et al. 1998, Falasca et al. 1998).

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