Reactome | PI3K phosphorylates PIP2 to PIP3

PI3K phosphorylates PIP2 to PIP3

Stable Identifier

R-HSA-2424480

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. Products of PI3K are involved in the regulation of PLC-gamma 1 and VAV activation. The PH domain of PLC-gamma 1 binds to PIP3 and is targeted to the membrane. PIP3 binds to the PH domain of VAV2/VAV3 and increases it activity and PI3K may also strongly stimulate VAV activity by converting an inhibitory regulator VAV to an activator (Toker & Cantley 1997, Fischer et al. 1998, Falasca et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
15536084	Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase Moon, KD, Durden, DL, Post, CB, De, P, Geahlen, RL, Harrison, ML, Zhou, Q	J Biol Chem	2005
12660731	The role of PI3K in immune cells Koyasu, S	Nat Immunol	2003