Reactome | PI3K phosphorylates PIP2 to PIP3

PI3K phosphorylates PIP2 to PIP3

Stable Identifier

R-HSA-2424480

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

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Activated PI3K phosphorylates phosphatidylinositol (PI) 4-phosphate and PI 4,5-bisphosphate (PIP2) to generate PI 3,4-bisphosphate and PI 3,4,5-triphosphate (PIP3) and these second messengers recruit other signaling proteins containing plecstrin homology (PH) domain. Products of PI3K are involved in the regulation of PLC-gamma 1 and VAV activation. The PH domain of PLC-gamma 1 binds to PIP3 and is targeted to the membrane. PIP3 binds to the PH domain of VAV2/VAV3 and increases it activity and PI3K may also strongly stimulate VAV activity by converting an inhibitory regulator VAV to an activator (Toker & Cantley 1997, Fischer et al. 1998, Falasca et al. 1998).

Literature References

PubMed ID	Title	Journal	Year
12660731	The role of PI3K in immune cells Koyasu, S	Nat Immunol	2003
15536084	Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase Moon, KD, Post, CB, Durden, DL, Zhou, Q, De, P, Harrison, ML, Geahlen, RL	J Biol Chem	2005