Activation of RAC1 by VAV2/3

Stable Identifier
R-HSA-2424476
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Activated VAV2/3 act as guanine nucleotide exchange factors (GEFs) for RAC-1, catalysing the exchange of bound GDP for GTP.
Literature References
PubMed ID Title Journal Year
11094073 Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

Welsh, J, Sachdev, P, Yan, L, Zeng, L, Trenkle, T, Wang, LH, Chan, JL, McClelland, M

Mol. Cell. Biol. 2000
10744696 Vav2 is an activator of Cdc42, Rac1, and RhoA

Rossman, KL, Burridge, K, Campbell, SL, Abe, K, Ritola, KD, Chiang, D, Der, CJ, Liu, B

J. Biol. Chem. 2000
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!