Activation of RAC1 by VAV2/3

Stable Identifier
R-HSA-2424476
Type
Reaction
Species
Homo sapiens
Compartment
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Activated VAV2/3 act as guanine nucleotide exchange factors (GEFs) for RAC-1, catalysing the exchange of bound GDP for GTP.

Literature References
PubMed ID Title Journal Year
11094073 Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

Welsh, J, Sachdev, P, Yan, L, Zeng, L, Trenkle, T, Wang, LH, Chan, JL, McClelland, M

Mol. Cell. Biol. 2000
10744696 Vav2 is an activator of Cdc42, Rac1, and RhoA

Rossman, KL, Burridge, K, Campbell, SL, Abe, K, Ritola, KD, Chiang, D, Der, CJ, Liu, B

J. Biol. Chem. 2000
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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