Activation of RAC1 by VAV2/3

Stable Identifier
R-HSA-2424476
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Activation of RAC1 by VAV2/3
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Activated VAV2/3 act as guanine nucleotide exchange factors (GEFs) for RAC-1, catalysing the exchange of bound GDP for GTP.

Literature References
PubMed ID Title Journal Year
11094073 Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

Welsh, J, Sachdev, P, Yan, L, Zeng, L, Trenkle, T, Wang, LH, Chan, JL, McClelland, M

Mol. Cell. Biol. 2000
10744696 Vav2 is an activator of Cdc42, Rac1, and RhoA

Rossman, KL, Burridge, K, Campbell, SL, Abe, K, Ritola, KD, Chiang, D, Der, CJ, Liu, B

J. Biol. Chem. 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

guanyl-nucleotide exchange factor activity of p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]

Physical Entity
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
Activation of RAC1 by VAV2/3 (Bos taurus)
Activation of RAC1 by VAV2/3 (Canis familiaris)
Activation of RAC1 by VAV2/3 (Danio rerio)
Activation of RAC1 by VAV2/3 (Drosophila melanogaster)
Activation of RAC1 by VAV2/3 (Gallus gallus)
Activation of RAC1 by VAV2/3 (Mus musculus)
Activation of RAC1 by VAV2/3 (Rattus norvegicus)
Activation of RAC1 by VAV2/3 (Sus scrofa)
Activation of RAC1 by VAV2/3 (Xenopus tropicalis)
Authored
Garapati, P V  (2012-05-25)
Reviewed
Lanier, LL  (2012-08-09)
Created
Garapati, P V  (2012-07-23)
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