Activation of RAC1 by VAV2/3

Stable Identifier
R-HSA-2424476
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activated VAV2/3 act as guanine nucleotide exchange factors (GEFs) for RAC-1, catalysing the exchange of bound GDP for GTP.

Literature References
PubMed ID Title Journal Year
10744696 Vav2 is an activator of Cdc42, Rac1, and RhoA

Abe, K, Rossman, KL, Liu, B, Ritola, KD, Chiang, D, Campbell, SL, Burridge, K, Der, CJ

J. Biol. Chem. 2000
11094073 Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

Zeng, L, Sachdev, P, Yan, L, Chan, JL, Trenkle, T, McClelland, M, Welsh, J, Wang, LH

Mol. Cell. Biol. 2000
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created