Reactome | Activation of RAC1 by VAV2/3

Schema > Reaction > Entries

Activation of RAC1 by VAV2/3 Show undefined attributes

catalystActivity	[CatalystActivity:9925552] guanyl-nucleotide exchange factor activity of p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9925554
displayName	Activation of RAC1 by VAV2/3
eventOf	[Pathway:R-MMU-2424491] DAP12 signaling - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2424476] Activation of RAC1 by VAV2/3 - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-445010] RAC1:GDP [cytosol]
isInDisease	false
isInferred	true
name	Activation of RAC1 by VAV2/3
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-421103] Rac1-GTP [cytosol]
precedingEvent	[Reaction:R-MMU-2424486] Phosphorylation and activation of VAV2/VAV3 by SYK - Mus musculus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2424476
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2424491] DAP12 signaling
(inferredTo)	[Reaction:R-HSA-2424476] Activation of RAC1 by VAV2/3