MeSec is hydrolysed to MeSeH by PXLP-K212-CTH

Stable Identifier
R-HSA-2408539
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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MeSec is hydrolysed to MeSeH by PXLP-K212-CTH
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Methylselenocysteine (MeSec) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and pyruvic acid. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) (Pinto et al. 2011, Suzuki et al. 2007).

Literature References
PubMed ID Title Journal Year
17451884 Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide

Suzuki, KT, Suzuki, N, Kurasaki, K

Biochim. Biophys. Acta 2007
20383543 Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds

Cooper, AJ, Sinha, R, Lee, JI, Pinto, JT, MacEwan, ME

Amino Acids 2011
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Catalyst Activity

methylselenocysteine deselenhydrase activity of PXLP-K212-CTH tetramer [cytosol]

Physical Entity
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
Activity
methylselenocysteine deselenhydrase activity (GO:0098607)
Inferred From
MeSec is hydrolysed to MeSeH by PXLP-K211-Cth (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
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