MeSec is hydrolysed to MeSeH by PXLP-K212-CTH

Stable Identifier
R-HSA-2408539
Type
Reaction
Species
Homo sapiens
Compartment
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Methylselenocysteine (MeSec) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and pyruvic acid. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) (Pinto et al. 2011, Suzuki et al. 2007).

Literature References
PubMed ID Title Journal Year
17451884 Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide

Suzuki, KT, Suzuki, N, Kurasaki, K

Biochim. Biophys. Acta 2007
20383543 Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds

Cooper, AJ, Sinha, R, Lee, JI, Pinto, JT, MacEwan, ME

Amino Acids 2011
Participants
Participates
Catalyst Activity

methylselenocysteine deselenhydrase activity of PXLP-K212-CTH tetramer [cytosol]

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