MeSec is hydrolysed to MeSeH by PXLP-K212-CTH

Stable Identifier
R-HSA-2408539
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
MeSec is hydrolysed to MeSeH by PXLP-K212-CTH
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Methylselenocysteine (MeSec) undergoes an alpha,gamma-elimination reaction by cystathionine gamma-lyase (CTH) to produce methylselenol aka methaneselenol (MeSeH), ammonia, and pyruvic acid. This reaction is inferred from the event in rat involving the protein cystathionine gamma-lyase (Cth) (Pinto et al. 2011, Suzuki et al. 2007).

Literature References
PubMed ID Title Journal Year
17451884 Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide

Suzuki, KT, Suzuki, N, Kurasaki, K

Biochim. Biophys. Acta 2007
20383543 Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds

Cooper, AJ, Sinha, R, Lee, JI, Pinto, JT, MacEwan, ME

Amino Acids 2011
Participants
Input
Output
Participates
as an event of
Catalyst Activity

methylselenocysteine deselenhydrase activity of PXLP-K212-CTH tetramer [cytosol]

Physical Entity
PXLP-K212-CTH tetramer [cytosol] (Homo sapiens)
Activity
methylselenocysteine deselenhydrase activity (GO:0098607)
Inferred From
MeSec is hydrolysed to MeSeH by PXLP-K211-Cth (Rattus norvegicus)
Authored
Williams, MG  (2014-05-06)
Reviewed
Rush, MG  (2015-08-30)
Created
Williams, MG  (2012-07-17)
Cite Us!