Reactome | Recruitment of GRB2:SOS to p-5Y-LAT

Schema > Reaction > Entries

Recruitment of GRB2:SOS to p-5Y-LAT Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10044572
displayName	Recruitment of GRB2:SOS to p-5Y-LAT
eventOf	[Pathway:R-MMU-2871796] FCERI mediated MAPK activation - Mus musculus [Pathway:R-MMU-2424491] DAP12 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2424477] SOS mediated nucleotide exchange of RAS (SHC) - Mus musculus [Reaction:R-MMU-2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT - Mus musculus [Reaction:R-MMU-5672965] RAS GEFs promote RAS nucleotide exchange - Mus musculus
inferredFrom	[Reaction:R-HSA-2396599] Recruitment of GRB2:SOS to p-5Y-LAT - Homo sapiens
input	[Complex:R-MMU-2685672] p-SHC1:GRB2:SOS [cytosol] [EntityWithAccessionedSequence:R-MMU-2396597] phospho-Lat [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Recruitment of GRB2:SOS to p-5Y-LAT
output	[Complex:R-MMU-2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-2730844] Interaction of GRB2:SOS complex with p-SHC1 - Mus musculus [Reaction:R-MMU-2395801] Phosphorylation of LAT by p-SYK - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2396599
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2424491] DAP12 signaling [Pathway:R-MMU-2871796] FCERI mediated MAPK activation
(precedingEvent)	[Reaction:R-MMU-2424477] SOS mediated nucleotide exchange of RAS (SHC) [Reaction:R-MMU-2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT [Reaction:R-MMU-5672965] RAS GEFs promote RAS nucleotide exchange
(inferredTo)	[Reaction:R-HSA-2396599] Recruitment of GRB2:SOS to p-5Y-LAT