Reactome | SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

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SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL Show undefined attributes

authored	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:2186727] Orlic-Milacic, M, 2012-04-05
dbId	2186741
displayName	SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10 [InstanceEdit:9773750] Orlic-Milacic, Marija, 2022-05-09
eventOf	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Homo sapiens
followingEvent	[Reaction:R-HSA-2186747] Ubiquitination of SKI/SKIL by RNF111/SMURF2 - Homo sapiens
inferredFrom	[Reaction:R-NUL-2186736] Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation - Homo sapiens
input	[Complex:R-HSA-177110] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR [nucleoplasm] [CandidateSet:R-HSA-2186743] RNF111/SMURF2 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2186628] TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation [LiteratureReference:2186730] Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL
negativePrecedingEvent	[NegativePrecedingEvent:9754411] Futile Cycle: RNF111 ubiquitinates SMAD7 [NegativePrecedingEvent:9754408] Futile Cycle: SMURF2 monoubiquitinates SMAD3 [NegativePrecedingEvent:9754429] Futile Cycle: Ubiquitination of SKI/SKIL by RNF111/SMURF2
output	[Complex:R-HSA-2186744] p-2S-SMAD2,3:SMAD4:SKI/SKIL:NCOR:RNF111/SMURF2 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-173481] SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14 [InstanceEdit:9773670] Contreras, Osvaldo, 2022-05-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2186741
summation	[Summation:2186759] After phosphorylated SMAD2/3 accumulate in the nucleus in re...

Referrals

(hasEvent)	[Pathway:R-HSA-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(precedingEvent)	[Reaction:R-HSA-2186747] Ubiquitination of SKI/SKIL by RNF111/SMURF2
(inferredTo)	[Reaction:R-NUL-2186736] Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation

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