Reactome | SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

Stable Identifier

R-HSA-2186741

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

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After phosphorylated SMAD2/3 accumulate in the nucleus in response to TGF-beta stimulation, E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007) and SMURF2 (Bonni et al. 2001) bind SKI/SKIL in complex with SMAD2/3:SMAD4 heterotrimer. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL (Levy et al. 2007). The role of SMURF2 was inferred from experiments involving human proteins only (Bonni et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11389444	TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation Bonni, S, Wang, HR, Causing, CG, Kavsak, P, Stroschein, SL, Luo, K, Wrana, JL	Nat Cell Biol	2001
17591695	Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation Levy, L, Howell, M, Das, D, Harkin, S, Episkopou, V, Hill, CS	Mol Cell Biol	2007