SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

Stable Identifier
R-HSA-2186741
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL
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After phosphorylated SMAD2/3 accumulate in the nucleus in response to TGF-beta stimulation, E3 ubiqutin ligases RNF111 (Arkadia) (Levy et al. 2007) and SMURF2 (Bonni et al. 2001) bind SKI/SKIL in complex with SMAD2/3:SMAD4 heterotrimer. The role of RNF111 was inferred from experiments that used recombinant mouse RNF111 and endogenous human SMADs and SKI/SKIL (Levy et al. 2007). The role of SMURF2 was inferred from experiments involving human proteins only (Bonni et al. 2001).

Literature References
PubMed ID Title Journal Year
11389444 TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

Bonni, S, Wang, HR, Causing, CG, Kavsak, P, Stroschein, SL, Luo, K, Wrana, JL

Nat Cell Biol 2001
17591695 Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

Levy, L, Howell, M, Das, D, Harkin, S, Episkopou, V, Hill, CS

Mol Cell Biol 2007
Participants
Input
Output
Participant Of
hasEvent
Inferred From
Rnf111 binds SKI/SKIL in complex with SMAD2/3:SMAD4 upon TGF-beta stimulation (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-05)