Reactome | MEN1 binds SMAD2/3:SMAD4 heterotrimer

MEN1 binds SMAD2/3:SMAD4 heterotrimer

Stable Identifier

R-HSA-2186643

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MEN1 (menin), a transcription factor tumor suppressor mutated in a familial cancer syndrome multiple endocrine neoplasia type 1, binds SMAD2/3:SMAD4 heterotrimer through interaction with SMAD3. MEN1 likely acts as a trancriptional cofactor for SMAD2/3:SMAD4 and may be involved in transcriptional regulation of some SMAD2/3:SMAD4 target genes (Kaji et al. 2001, Sowa et al. 2004, Canaff et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
15150273	Menin is required for bone morphogenetic protein 2- and transforming growth factor beta-regulated osteoblastic differentiation through interaction with Smads and Runx2 Kaji, H, Sowa, H, Komori, T, Canaff, L, Chihara, K, Sugimoto, T, Hendy, GN	J Biol Chem	2004
22275377	Impaired Transforming Growth Factor-? (TGF-?) Transcriptional Activity and Cell Proliferation Control of a Menin In-frame Deletion Mutant Associated with Multiple Endocrine Neoplasia Type 1 (MEN1) Kaji, H, Vanbellinghen, JF, Canaff, L, Goltzman, D, Hendy, GN	J Biol Chem	2012
11274402	Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type beta signaling Kaji, H, Lebrun, JJ, Canaff, L, Goltzman, D, Hendy, GN	Proc Natl Acad Sci U S A	2001