Reactome | DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)

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DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1) Show undefined attributes

authored	[InstanceEdit:386943] Williams, MG, 2006-09-21 16:49:12
catalystActivity	[CatalystActivity:208911] ubiquitin-protein transferase activity of NEUR/MIB1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:205681] Williams, MG, 2006-09-21 15:05:28
dbId	209226
displayName	DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)
edited	[InstanceEdit:2106576] Orlic-Milacic, M, 2012-02-10 [InstanceEdit:2098673] D'Eustachio, P, 2012-02-06
entityOnOtherCell	[DefinedSet:R-DME-206545] DL/SER [plasma membrane] - Drosophila melanogaster [DefinedSet:R-DME-206587] NEUR/MIB1 [cytosol] - Drosophila melanogaster [DefinedSet:R-DME-206204] UBI-P63E [cytosol] - Drosophila melanogaster
figure	[Figure:208733] /figures/DrosNotch05A.jpg
input	[Complex:R-DME-207038] Fucosylated N:DL/SER [plasma membrane] [DefinedSet:R-DME-206204] UBI-P63E [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:208262] The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta [LiteratureReference:208089] Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila [LiteratureReference:208396] The interplay between DSL proteins and ubiquitin ligases in Notch signaling [LiteratureReference:208133] Drosophila neuralized is a ubiquitin ligase that promotes the internalization and degradation of delta
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	DL/SER is ubiquitinated by E3 ubiquitination ligases (NEUR/MIB1)
orthologousEvent	[Reaction:R-HSA-2172172] Ubiquitination of DLL/JAG ligands upon binding to NOTCH2 - Homo sapiens [Reaction:R-HSA-1980074] Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 - Homo sapiens [Reaction:R-HSA-9013069] Ubiquitination of DLL/JAG ligands upon binding to NOTCH3 - Homo sapiens
output	[Complex:R-DME-206647] Fucosylated N:UBI-P63E:DL/SER [plasma membrane]
releaseDate	2012-03-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2121207] Haw, R, 2012-02-06
revised	[InstanceEdit:2121208] Egan, SE, Orlic-Milacic, M, 2011-11-14
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-209226
summation	[Summation:216337] The E3 ubiquitin ligases Neuralized (NEUR) or Mind Bomb 1 (M...

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