Reactome | COQ4 decarboxylates MHDB

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COQ4 decarboxylates MHDB Show undefined attributes

authored	[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity	[CatalystActivity:2167850] 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity of COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:2162189] Williams, MG, 2012-03-15
crossReference	[DatabaseIdentifier:12667902] RHEA:81275
dbId	2162195
displayName	COQ4 decarboxylates MHDB
edited	[InstanceEdit:2167908] Williams, MG, 2012-03-23
eventOf	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2162191] Unknown enzyme hydroxylates DMPhOH - Homo sapiens
input	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-2162215] MHDB [mitochondrial inner membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9909191] COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells [LiteratureReference:9909211] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	COQ4 decarboxylates MHDB MHDB is decarboxylated to DMPhOH
orthologousEvent	[Reaction:R-SCE-2162195] COQ4 decarboxylates MHDB - Saccharomyces cerevisiae [Reaction:R-SPO-2162195] COQ4 decarboxylates MHDB - Schizosaccharomyces pombe [Reaction:R-DDI-2162195] COQ4 decarboxylates MHDB - Dictyostelium discoideum [Reaction:R-CEL-2162195] COQ4 decarboxylates MHDB - Caenorhabditis elegans [Reaction:R-DME-2162195] COQ4 decarboxylates MHDB - Drosophila melanogaster [Reaction:R-GGA-2162195] COQ4 decarboxylates MHDB - Gallus gallus [Reaction:R-XTR-2162195] COQ4 decarboxylates MHDB - Xenopus tropicalis [Reaction:R-DRE-2162195] COQ4 decarboxylates MHDB - Danio rerio [Reaction:R-SSC-2162195] COQ4 decarboxylates MHDB - Sus scrofa [Reaction:R-BTA-2162195] COQ4 decarboxylates MHDB - Bos taurus [Reaction:R-CFA-2162195] COQ4 decarboxylates MHDB - Canis familiaris [Reaction:R-RNO-2162195] COQ4 decarboxylates MHDB - Rattus norvegicus [Reaction:R-MMU-2162195] COQ4 decarboxylates MHDB - Mus musculus
output	[SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-2162208] DMPhOH [mitochondrial inner membrane]
precedingEvent	[Reaction:R-HSA-2162193] COQ3 methylates DHDB - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02 [InstanceEdit:9909593] Marchi, Marco, 2024-05-14 [InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2162195
summation	[Summation:2167906] COQ4 is a zinc-dependent enzyme that catalyzes the decarboxy...
updateTrackers	[UpdateTracker:9910994] Update Tracker - [Reaction:2162195] COQ4 decarboxylates MHDB - v89:[add_removeLiteratureReference, modifyText] [UpdateTracker:9864073] Update Tracker - [BlackBoxEvent:2162195] Unknown enzyme decarboxylates MHDB - v88:[addInput]

Referrals

(updatedInstance)	[UpdateTracker:9910994] Update Tracker - [Reaction:2162195] COQ4 decarboxylates MHDB - v89:[add_removeLiteratureReference, modifyText] [UpdateTracker:9864073] Update Tracker - [BlackBoxEvent:2162195] Unknown enzyme decarboxylates MHDB - v88:[addInput]
(hasEvent)	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis
(precedingEvent)	[BlackBoxEvent:R-HSA-2162191] Unknown enzyme hydroxylates DMPhOH

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