COQ4 is a zinc-dependent enzyme that catalyzes the decarboxy...

created [InstanceEdit:2167896] Williams, MG, 2012-03-23
dbId 2167906
displayName COQ4 is a zinc-dependent enzyme that catalyzes the decarboxy...
modified [InstanceEdit:9909243] Stephan, Ralf, 2024-05-01
schemaClass Summation
text COQ4 is a zinc-dependent enzyme that catalyzes the decarboxylation step in CoQ biosynthesis (Pelosi et al., 2024 and Nicoll et al., 2024). However, the substrate and the product of the decarboxylation step remain ambiguous since Nicoll et al. reported a decarboxylation of 3-methoxy-4-hydroxy-5-decaprenylbenzoate (MHDB) into 2-methoxy-6-decaprenylphenol (DMPhOH), whereas Pelosi et al. proposed that COQ4 catalyzes an oxidative decarboxylation which yields a hydroxylated product. In this case, DHB rather than MHDB was proposed a substrate for COQ4, generating 3-polyprenyl-4-hydroxyphenol as a product. We are provisionally showing the first reaction until more data is available.
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