Reactome | Unknown enzyme hydroxylates DMPhOH

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Unknown enzyme hydroxylates DMPhOH Show undefined attributes

authored	[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity	[CatalystActivity:2167847] monooxygenase activity of DMPhOH monooxygenase [mitochondrial matrix]
category	omitted
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:2162189] Williams, MG, 2012-03-15
dbId	2162191
displayName	Unknown enzyme hydroxylates DMPhOH
edited	[InstanceEdit:2167908] Williams, MG, 2012-03-23
eventOf	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2162188] COQ5 methylates MDMQ10H2 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-SCE-2164813] HMPhOH is hydroxylated to MDMQ6H2 by HMPhOH monooxygenase - Saccharomyces cerevisiae
input	[SimpleEntity:R-ALL-2162208] DMPhOH [mitochondrial inner membrane] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix] [SimpleEntity:R-ALL-113533] O2 [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2162288] Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency [LiteratureReference:2162300] The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis [LiteratureReference:9909191] COQ4 is required for the oxidative decarboxylation of the C1 carbon of Coenzyme Q in eukaryotic cells [LiteratureReference:9909211] In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis
maxDepth	1
modified	[InstanceEdit:9910562] Stephan, Ralf, 2024-05-15
name	Unknown enzyme hydroxylates DMPhOH DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase
output	[SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix] [SimpleEntity:R-ALL-2162205] MDMQ10H2 [mitochondrial inner membrane] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-2162195] COQ4 decarboxylates MHDB - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02 [InstanceEdit:9909593] Marchi, Marco, 2024-05-14 [InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2162191
summation	[Summation:2167905] The enzymatic conversion of 2-methoxy-6-decaprenylphenol (DM...
updateTrackers	[UpdateTracker:9910941] Update Tracker - [BlackBoxEvent:2162191] Unknown enzyme hydroxylates DMPhOH - v89:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9910941] Update Tracker - [BlackBoxEvent:2162191] Unknown enzyme hydroxylates DMPhOH - v89:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis
(precedingEvent)	[Reaction:R-HSA-2162188] COQ5 methylates MDMQ10H2
(inferredTo)	[BlackBoxEvent:R-SCE-2164813] HMPhOH is hydroxylated to MDMQ6H2 by HMPhOH monooxygenase