The enzymatic conversion of 2-methoxy-6-decaprenylphenol (DM...

created [InstanceEdit:2167896] Williams, MG, 2012-03-23
dbId 2167905
displayName The enzymatic conversion of 2-methoxy-6-decaprenylphenol (DM...
modified [InstanceEdit:9909243] Stephan, Ralf, 2024-05-01
schemaClass Summation
text The enzymatic conversion of 2-methoxy-6-decaprenylphenol (DMPhOH) to 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2) is inferred from the equivalent reaction in yeast (Gin et al. 2003, Ozeir et al. 2011). . It was thought at one time that the flavin dependent monooxygenase, COQ6, was the enzyme that catalysed this reaction, however, it has been subsequently shown that COQ6 is not essential for this reaction (Ozeir et al. 2011). Yet, Nicoll et al. reported low levels of in vitro activity for a resurrected ancestral COQ6, opening the possibility that COQ6 might be a bifunctional hydroxylase operating on carbon C5 and C1 of CoQ precursors (Nicoll et al., 2024). Note that the proposal by Pelosi et al. that COQ4 catalyzes an oxidative decarboxylation eliminates reaction from the CoQ biosynthesis pathway (Pelosi et al., 2024) is an alternative hypothesis.
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