2-methoxy-6-decaprenylphenol (DMPhOH) is enzymatically converted to 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2). It was thought at one time that the flavin-dependent monooxygenase, COQ6, was the enzyme that catalysed this reaction, however, it has been subsequently shown that COQ6 is not essential for this reaction (Ozeir et al. 2011). However, it is still believed that another member of the COQ family catalyses this event. This reaction is inferred from the equivalent reaction in yeast (Gin et al. 2003, Ozeir et al. 2011).
Tzagoloff, A, Rothman, SC, Jonassen, T, Hsu, AY, Gin, P, Lee, PT, Clarke, CF
Ozeir, M, Fontecave, M, Lill, R, Pierrel, F, Webert, H, Mühlenhoff, U
monooxygenase activity of DMPhOH monooxygenase [mitochondrial matrix]
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