DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase

Stable Identifier
R-HSA-2162191
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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2-methoxy-6-decaprenylphenol (DMPhOH) is enzymatically converted to 2-methoxy-6-decaprenyl-1,4-benzoquinol (MDMQ10H2). It was thought at one time that the flavin-dependent monooxygenase, COQ6, was the enzyme that catalysed this reaction, however, it has been subsequently shown that COQ6 is not essential for this reaction (Ozeir et al. 2011). However, it is still believed that another member of the COQ family catalyses this event. This reaction is inferred from the equivalent reaction in yeast (Gin et al. 2003, Ozeir et al. 2011).

Literature References
PubMed ID Title Journal Year
21944752 Coenzyme Q biosynthesis: Coq6 is required for the C5-hydroxylation reaction and substrate analogs rescue Coq6 deficiency

Ozeir, M, Mühlenhoff, U, Webert, H, Lill, R, Fontecave, M, Pierrel, F

Chem Biol 2011
12721307 The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis

Gin, P, Hsu, AY, Rothman, SC, Jonassen, T, Lee, PT, Tzagoloff, A, Clarke, CF

J Biol Chem 2003
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Catalyst Activity
Title
monooxygenase activity of DMPhOH monooxygenase [mitochondrial matrix]
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