Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15

Stable Identifier
Reaction [transition]
Homo sapiens
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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) (Funk et al. 1990, Izumi et al. 1990) and arachidonate 15-lipoxygenase (ALOX15) (Kuhn et al. 1993, Sigal et al. 1990) convert arachidonic acid into 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE).

Literature References
PubMed ID Title Journal Year
8334154 Overexpression, purification and characterization of human recombinant 15-lipoxygenase

Bursztyn-Pettegrew, H, Chow, J, Baecker, P, Grunberger, D, Kühn, H, Barnett, J, Sigal, E, Chan, H, Nguyen, B

Biochim Biophys Acta 1993
2377602 Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase

FitzGerald, GA, Funk, CD, Furci, L

Proc Natl Acad Sci U S A 1990
2318885 Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related

Grunberger, D, Dixon, RA, Craik, CS, Gross, C, Highland, E, Sigal, E

J Biol Chem 1990
2217179 Cloning of the cDNA for human 12-lipoxygenase

Rådmark, O, Hoshiko, S, Izumi, T, Samuelsson, B

Proc Natl Acad Sci U S A 1990
Catalyst Activity

arachidonate 12(S)-lipoxygenase activity of ALOX12/15 [cytosol]

Orthologous Events
Cross References
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