Reactome | Arachidonate is oxidised to 12S-HpETE by ALOX12/15

Arachidonate is oxidised to 12S-HpETE by ALOX12/15

Stable Identifier

R-HSA-2161964

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate

ReviewStatus

5/5

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Arachidonate is oxidised to 12S-HpETE by ALOX12/15

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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) (Funk et al. 1990, Izumi et al. 1990) and arachidonate 15-lipoxygenase (ALOX15) (Kuhn et al. 1993, Sigal et al. 1990) convert arachidonate into 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE).

Literature References

PubMed ID	Title	Journal	Year
8334154	Overexpression, purification and characterization of human recombinant 15-lipoxygenase Kühn, H, Barnett, J, Grunberger, D, Baecker, P, Chow, J, Nguyen, B, Bursztyn-Pettegrew, H, Chan, H, Sigal, E	Biochim Biophys Acta	1993
2377602	Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase Funk, CD, Furci, L, FitzGerald, GA	Proc Natl Acad Sci U S A	1990
2318885	Expression of cloned human reticulocyte 15-lipoxygenase and immunological evidence that 15-lipoxygenases of different cell types are related Sigal, E, Grunberger, D, Highland, E, Gross, C, Dixon, RA, Craik, CS	J Biol Chem	1990
2217179	Cloning of the cDNA for human 12-lipoxygenase Izumi, T, Hoshiko, S, Rådmark, O, Samuelsson, B	Proc Natl Acad Sci U S A	1990