Reactome | Arachidonate is oxidised to 12S-HpETE by ALOX12/15

Schema > Reaction > Entries

Arachidonate is oxidised to 12S-HpETE by ALOX12/15 Show undefined attributes

catalystActivity	[CatalystActivity:10277332] arachidonate 12(S)-lipoxygenase activity of ALOX12/15 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10277334
displayName	Arachidonate is oxidised to 12S-HpETE by ALOX12/15
eventOf	[Pathway:R-CFA-2142712] Synthesis of 12-eicosatetraenoic acid derivatives - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-2161999] 12S-HpETE is reduced to 12S-HETE by GPX1/2/4 - Canis familiaris
inferredFrom	[Reaction:R-HSA-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15 - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Arachidonate is oxidised to 12S-HpETE by ALOX12/15 (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
output	[SimpleEntity:R-ALL-2142811] 12S-HpETE [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-2161964
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2142712] Synthesis of 12-eicosatetraenoic acid derivatives
(precedingEvent)	[Reaction:R-CFA-2161999] 12S-HpETE is reduced to 12S-HETE by GPX1/2/4
(inferredTo)	[Reaction:R-HSA-2161964] Arachidonate is oxidised to 12S-HpETE by ALOX12/15

Cite Us!